iMatrix-332's features make it an ideal matrix for some cell culture applications:
- Xeno-free formulation / CHO-S cell bioproduction
- Easy to use (liquid format)
- E8-fragments retain integrin binding specificity and capacity, and display higher potency than natural Laminin-221
iMatrix-332 is a highly purified and refined product of human recombinant laminin-332 (E8 fragment) expressed by CHO-S cells. Laminin 332 supports cells in the epithelial basement membranes, lining the surfaces of the body such as the skin, hair follicles, oral cavity, gastrointestinal and urinary tracts, lungs, and different glands. The association of cells with laminin 332 occurs through α3β1 integrin in focal adhesions and α6β4 in stable anchoring contacts, which contain an assembly of hemidesmosome proteins.
Laminin-332 is an important component of the "skin basement membrane" that exists between the epithelium and dermis of the skin, and is also expressed in human retinal pigment epithelium (RPE) and hair follicle cells.
Specifications
Product Name: iMatrix-332 Corneal Epiethelial Cell Culture Substrate
Catalog Numbers:
- NP892-031
- NP892-032
Sizes:
- NP892-031 — 2 × 175 µg
- NP892-032 — 6 × 175 µg
Molecular Weight: 150 kDa
Purity: > 95 % pure
Formulation: Purified Laminin-332 E8 proteolytic fragment
Storage and Stability: Store at 4 °C and protect from light exposure. Stable for 2 years from manufacturing date.
Quality Control: Activity: Kd for integrin binding
Sterility: Sterile
Notice To Purchaser: REPROCELL is a licensed distributor of Matrixome cell culture substrates to the global market.
Recommended Usage: iMatrix-332 is suitable for use as a substrate for culture of various cell types.
Concentration: 500 µg/mL
Source: CHO-S cell expression
Manufacturer: Matrixome Corporation (Japan)
Documents
Safety Data Sheets:
Product Flyer: