Achieve early indication of clinical drug performance using ethically sourced human fresh tissues. Human ex vivo assays bridge the gap between animal studies and clinical trials — streamlining the drug discovery process and accelerating your test article pipeline. With our unparalleled access to ethically donated human tissue, REPROCELL has developed the most clinically relevant functional human tissue models, that avoid species differences, improve understanding of disease pathology and reduce clinical attrition by demonstrating proof of concept in human disease.
Some examples of the studies we frequently conduct:
Organoculture systems to investigate inflammatory responses (cytokine release) in skin (normal, psoriasis, atopic dermatitis) gastrointestinal tissues (normal and IBD) and lung (normal, COPD, and asthma).
Cardiac contractility in failing and non-failing hearts for efficacy studies or to detect cardiovascular safety risks.
Smooth muscle contractility in blood vessels, airways, stomach, small intestine, colon, bladder, etc.
Mucosal ion channel assays, investigating sodium, chloride, and potassium channels in intact mucosa of the respiratory and gastrointestinal systems.
Permeability of test compounds through tracheal mucosa or the gastrointestinal tract
Our experienced team can analyze a range of endpoints using human intact fresh tissues to complete your customized project.
Small molecule or other drug treatment of iPSC-derived cell lines followed by analysis (survival, fate, proliferation, etc.)
Additionally, we will soon be launching a clinical iPSC manufacturing service in which we can identify donors, collect tissue, derive seed stock iPSCs, and generate Master and Working Cell Banks in accordance with clinical regulatory guidelines.
The REPROCELL Bioserve Global Biorepository is one of the largest commercial human tissue banks in the world. With more than 600,000 human serum, DNA, RNA, and FFPE samples, from over 120,000 patients on four continents, there is a good chance that the human DNA samples you need are already stored in the Biorepository.