Purchase product: USA Store
|Product Code||Pack Size||Price in
|Price in EMEA|
|04-0004||2 mg||USD $ 203.00||GBP £ 157.27||EUR € 178.51|
|04-0004-10||10 mg||USD $ 799.00||GBP £ 691.34||EUR € 784.69|
|04-0004-02||2 mg in solution (10 mM)||USD $ 239.00||GBP £ 185.03||EUR € 210.01|
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The aminopyrimidine CHIR99021 is the most selective inhibitor of glycogen synthase kinase 3 β (GSK-3β) reported to date1,2. Unlike other potent inhibitors of GSK-3, CHIR99201 does not exhibit cross-reactivity against cyclin-dependent kinases (CDKs) and shows a 350-fold selectivity toward GSK-3β compared to CDKs3. Along with the elimination of differentiation-inducing signaling from mitogen-activated protein kinases, using CHIR99021 to block the activity of GSK-3β enables the self-renewal of embryonic stem cells4.
Product Name: Stemolecule CHIR99021
Catalog Number: 04-0004
AlternateName(s): 6-[[2-[[4-(2,4-dichlorophenyl)-5-(5-methyl-1H-imidazol-2-yl)-2 pyrimidinyl]amino]ethyl]amino]-3-pyridinecarbonitrile
Chemical Formula: C22H18Cl2N8
Molecular Weight: 465.34
CAS Number: 252917-06-9
Purity: Greater than 95 % by HPLC analysis
Formulation: Off-white solid
Solubility: Reconstitute in DMSO to the desired concentration. For reconstitution instructions please reference product specifications sheet.
Storage and Stability: Store powder at 4 °C protected from light. Information about the stability of Stemolecules in solution is largely not available. As a general guideline, we recommend that stock solution be freshly made and stored in aliquots at −20 °C. The effect of storage of stock solutions should be verified for each application.
Quality Control: The purity of CHIR99021 was determined by HPLC analysis. The accurate mass was determined by mass spectrometry. Cellular toxicity of CHIR99021 was tested on mouse embryonic stem cells.
Stem Cell Reagents
3D Cell Culture
Zara Puckrin, BSc / 8 June 2021
Zara Puckrin, BSc / 31 May 2021
Lydia Costello, PhD / 25 May 2021
21 June 2021
24 May 2021
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