Atelocollagen Sponge, MIGHTY

KKN-CSM-25 / KKN-CSM-50

Brand: AteloCell® by KOKEN®

Purchase product: USA Store

Product Code Pack Size Price in
the Americas
Prices in UK, Europe,
Middle East & Africa
UK EU
KKN-CSM-25 25 pieces USD $ 704.00 GBP £ 631.73 EUR € 717.03
KKN-CSM-50 50 pieces USD $ 932.00 GBP £ 836.11 EUR € 949.01

Prices do not include shipping and handling charges.

atelocollagen-sponge-mighty-p336-131_medium

A "physically strong" collagen sponge (96-well plate size) derived from bovine dermal type I collagen that shows resistance to compressive loading. Culturing with dynamic stimulus (such as pressure) can mimic in-vivo-like cell response as shown in some arthritic cell culture models.

Applications

  • Cell culture under dynamic stimuli
  • 3D cell culture
  • Carrier for cell transplant

Features

  • Retains structural rigidity during repeated compression loading of 10-20 kPa
  • Sized for 96 well plates

Data

"Mechanical stimulus culture assay using MIGHTY." (K. Shimomura, K. Nakata et al. Osaka University, Faculty of Medicine)

Forty kPa of repeated compressive load for 1 hour induced the expression of PEG2, IL6 and IL8, which are correlated to arthritis, after three days cultivation on MIGHTY.

Dexamethasone (Dex), anti-inflammatory agent, reduced the expression of PEG2, IL6 and IL8 in a concentration-dependent manner. These results indicate MIGHTY can be used for in vitro arthritis models.

1536918928sponge-mighty-t1-01

Specifications

Product Name: Atelocollagen sponge, MIGHTY

Catalog Numbers:

  • KKN-CSM-25
  • KKN-CSM-50

Sizes:

  • KKN-CSM-25 — 25 pieces
  • KKN-CSM-50 — 50 pieces

Sponge Dimensions: 5 mm diameter × 3 mm sponges

Storage and Stability: Store at Room Temperature

Sterility: Sterile

Notice To Purchaser: REPROCELL is a licensed global distributor of KOKEN’s collagen-derived products everywhere, except for Japan.

Manufacturer: Koken Co., Ltd. (Japan)

References

  1. Shiozaki Y, et al. Enhanced in vivo osteogenesis by nanocarrier-fused bone morphogenetic protein-4. (2013) Int J Nanomedicine. 8:1349-1360.
  2. Akamine Y, et al. Prolonged matrix metalloproteinase-3 high expression after cycliccompressive load on human synovial cells in three-dimensional cultured tissue. (2012) Int J Oral Maxillofac Surg. 41(7):874-881.
  3. Muroi Y, et al. Effects of compressive loading on human synovium-derived cells. (2007) J Dent Res. 86(8):786-791.