Skip to megamenu (after main content)
Meet us next:   BIO International Convention 2025 – 4 September  ●  ELRIG – Drug Discovery in Scotland 2025 – 17 September  ●  The Cell & Gene Meeting on the Mesa 2025 – 6-8 October (in person) & 9-10 October (virtual)  ●  ELRIG – Drug Discovery – 21-22 October  ●  more on our events calendar
Prices for NutriStem, NutriCoat, and NutriFreez products will increase effective 1st August. Lock in the current price by getting your order by 31st July.

Atelocollagen Sponge, MIGHTY

KKN-CSM-25 / KKN-CSM-50

Brand: AteloCell®

Type 1 Atelocollagen sponge with heightened resistance to compressive loading.

Currency: 

Product name Catalog number KOKEN Code Pack size Price Price (USD) Price (GBP) Price (EUR)
Atelocollagen Sponge, MIGHTY KKN-CSM-25 CSM-25 25 pieces (select above) $ 801.00 £ 789.00 € 922.00
Atelocollagen Sponge, MIGHTY KKN-CSM-50 CSM-50 50 pieces (select above) $ 1,054.00 £ 1,041.00 € 1,216.00

USA Store

Note: prices shown do not include shipping and handling charges.

Product Information

A "physically strong" collagen sponge (96-well plate size) derived from bovine dermal type I collagen that shows resistance to compressive loading. Culturing with dynamic stimulus (such as pressure) can mimic in-vivo-like cell response as shown in some arthritic cell culture models.

Applications

  • Cell culture under dynamic stimuli
  • 3D cell culture
  • Carrier for cell transplant

Features

  • Retains structural rigidity during repeated compression loading of 10-20 kPa
  • Sized for 96 well plates

Data

"Mechanical stimulus culture assay using MIGHTY." (K. Shimomura, K. Nakata et al. Osaka University, Faculty of Medicine)

Forty kPa of repeated compressive load for 1 hour induced the expression of PEG2, IL6 and IL8, which are correlated to arthritis, after three days cultivation on MIGHTY.

Dexamethasone (Dex), anti-inflammatory agent, reduced the expression of PEG2, IL6 and IL8 in a concentration-dependent manner. These results indicate MIGHTY can be used for in vitro arthritis models.

1536918928sponge-mighty-t1-01


KOKEN company name and logo and AteloCell brand are the property of KOKEN Corp. Ltd., Japan.

Product Name: Atelocollagen sponge, MIGHTY

Catalog Numbers:

  • KKN-CSM-25
  • KKN-CSM-50

Sizes:

  • KKN-CSM-25 — 25 pieces
  • KKN-CSM-50 — 50 pieces

Sponge Dimensions: 5 mm diameter × 3 mm sponges

Storage and Stability: Store at Room Temperature

Sterility: Sterile

Notice To Purchaser: REPROCELL is a licensed global distributor of KOKEN’s collagen-derived products everywhere, except for Japan.

Manufacturer: Koken Co., Ltd. (Japan)

  1. Shiozaki Y, et al. Enhanced in vivo osteogenesis by nanocarrier-fused bone morphogenetic protein-4. (2013) Int J Nanomedicine. 8:1349-1360.
  2. Akamine Y, et al. Prolonged matrix metalloproteinase-3 high expression after cycliccompressive load on human synovial cells in three-dimensional cultured tissue. (2012) Int J Oral Maxillofac Surg. 41(7):874-881.
  3. Muroi Y, et al. Effects of compressive loading on human synovium-derived cells. (2007) J Dent Res. 86(8):786-791.