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Atelocollagen Sponge, MIGHTY

KKN-CSM-25 / KKN-CSM-50

Brand: AteloCell® by KOKEN®

EZSPHERE micro-well plates or dishes custom made to your specifications are possible.


Note: prices shown do not include shipping and handling charges.

Product code Pack size The Americas   UK, Europe, Middle East, Africa
(USD)   UK (GBP) Europe (EUR)

KKN-CSM-25
KKN-CSM-50

25 pieces
50 pieces

$ 739.00
$ 979.00

 

£ 663.32
£ 877.92

€ 752.88
€ 996.46

  USA store  
The Americas
Product code Pack size USD

KKN-CSM-25
KKN-CSM-50

25 pieces
50 pieces

$ 739.00
$ 979.00

USA store
UK, Europe, Middle East, Africa
Product code Pack size UK (GBP)

KKN-CSM-25
KKN-CSM-50

25 pieces
50 pieces

£ 663.32
£ 877.92

Europe (EUR)

KKN-CSM-25
KKN-CSM-50

25 pieces
50 pieces

€ 752.88
€ 996.46


atelocollagen-sponge-mighty-p336-131_medium

A "physically strong" collagen sponge (96-well plate size) derived from bovine dermal type I collagen that shows resistance to compressive loading. Culturing with dynamic stimulus (such as pressure) can mimic in-vivo-like cell response as shown in some arthritic cell culture models.

Applications

  • Cell culture under dynamic stimuli
  • 3D cell culture
  • Carrier for cell transplant

Features

  • Retains structural rigidity during repeated compression loading of 10-20 kPa
  • Sized for 96 well plates

Data

"Mechanical stimulus culture assay using MIGHTY." (K. Shimomura, K. Nakata et al. Osaka University, Faculty of Medicine)

Forty kPa of repeated compressive load for 1 hour induced the expression of PEG2, IL6 and IL8, which are correlated to arthritis, after three days cultivation on MIGHTY.

Dexamethasone (Dex), anti-inflammatory agent, reduced the expression of PEG2, IL6 and IL8 in a concentration-dependent manner. These results indicate MIGHTY can be used for in vitro arthritis models.

1536918928sponge-mighty-t1-01

Specifications

Product Name: Atelocollagen sponge, MIGHTY

Catalog Numbers:

  • KKN-CSM-25
  • KKN-CSM-50

Sizes:

  • KKN-CSM-25 — 25 pieces
  • KKN-CSM-50 — 50 pieces

Sponge Dimensions: 5 mm diameter × 3 mm sponges

Storage and Stability: Store at Room Temperature

Sterility: Sterile

Notice To Purchaser: REPROCELL is a licensed global distributor of KOKEN’s collagen-derived products everywhere, except for Japan.

Manufacturer: Koken Co., Ltd. (Japan)

References

  1. Shiozaki Y, et al. Enhanced in vivo osteogenesis by nanocarrier-fused bone morphogenetic protein-4. (2013) Int J Nanomedicine. 8:1349-1360.
  2. Akamine Y, et al. Prolonged matrix metalloproteinase-3 high expression after cycliccompressive load on human synovial cells in three-dimensional cultured tissue. (2012) Int J Oral Maxillofac Surg. 41(7):874-881.
  3. Muroi Y, et al. Effects of compressive loading on human synovium-derived cells. (2007) J Dent Res. 86(8):786-791.