Atelocollagen Sponge, MIGHTY
KKN-CSM-25 / KKN-CSM-50
Type 1 Atelocollagen sponge with heightened resistance to compressive loading.
|Product name||Product code||Pack size||Price (USD)||Price (GBP)||Price (EUR)|
|Atelocollagen Sponge, MIGHTY||KKN-CSM-25||25 pieces||$ 755.00||£ 744.81||€ 869.94|
|Atelocollagen Sponge, MIGHTY||KKN-CSM-50||50 pieces||$ 994.00||£ 981.04||€ 1,145.86|
Note: prices shown do not include shipping and handling charges.
A "physically strong" collagen sponge (96-well plate size) derived from bovine dermal type I collagen that shows resistance to compressive loading. Culturing with dynamic stimulus (such as pressure) can mimic in-vivo-like cell response as shown in some arthritic cell culture models.
- Cell culture under dynamic stimuli
- 3D cell culture
- Carrier for cell transplant
- Retains structural rigidity during repeated compression loading of 10-20 kPa
- Sized for 96 well plates
"Mechanical stimulus culture assay using MIGHTY." (K. Shimomura, K. Nakata et al. Osaka University, Faculty of Medicine)
Forty kPa of repeated compressive load for 1 hour induced the expression of PEG2, IL6 and IL8, which are correlated to arthritis, after three days cultivation on MIGHTY.
Dexamethasone (Dex), anti-inflammatory agent, reduced the expression of PEG2, IL6 and IL8 in a concentration-dependent manner. These results indicate MIGHTY can be used for in vitro arthritis models.
KOKEN company name and logo and AteloCell brand are the property of KOKEN Corp. Ltd., Japan.
Product Name: Atelocollagen sponge, MIGHTY
- KKN-CSM-25 — 25 pieces
- KKN-CSM-50 — 50 pieces
Sponge Dimensions: 5 mm diameter × 3 mm sponges
Storage and Stability: Store at Room Temperature
Notice To Purchaser: REPROCELL is a licensed global distributor of KOKEN’s collagen-derived products everywhere, except for Japan.
Manufacturer: Koken Co., Ltd. (Japan)
- Shiozaki Y, et al. Enhanced in vivo osteogenesis by nanocarrier-fused bone morphogenetic protein-4. (2013) Int J Nanomedicine. 8:1349-1360.
- Akamine Y, et al. Prolonged matrix metalloproteinase-3 high expression after cycliccompressive load on human synovial cells in three-dimensional cultured tissue. (2012) Int J Oral Maxillofac Surg. 41(7):874-881.
- Muroi Y, et al. Effects of compressive loading on human synovium-derived cells. (2007) J Dent Res. 86(8):786-791.