PRESS RELEASE: New Study Highlights Role of Stromal Support in Bioengineered Human Intestinal Models

[Durham University, United Kingdom]—A recent study led by Prof Stefan Przyborski, Professor of Cell Technology at Durham University, offers a pioneering approach to bioengineering human intestinal mucosa for drug discovery and testing. Published in MDPI’s Cells journal, this research paper emphasizes the importance of stromal support in replicating human intestinal structures in vitro, with implications for drug safety and efficacy studies.

The study details an advanced methodology for constructing intestinal mucosa using Alvetex® scaffolds, which includes vital stromal components. These components significantly improve cellular interactions, enhancing the physiological relevance of the model and offering a more accurate reflection of how drugs interact within the human intestine. Prof Przyborski’s work demonstrates that these models can potentially reduce the need for animal testing by providing more reliable human tissue-based assays, thus accelerating preclinical evaluation.

By incorporating stromal support, this research enhances the predictive power of bioengineered intestinal tissue in the Alvetex® platform, bridging a crucial gap in translational medicine. It marks a significant step forward for scientists and industry professionals who require precise models for pharmacological testing, particularly in drug absorption and metabolism.

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