The impact of fresh human tissue studies for translational work performed at Biopta has once again been demonstrated with this latest publication at the European Respiratory Society. This abstract describes the biological mechanisms by which a novel chemokine antagonist, AXP1275, impacts lung inflammation through its action at the CCR3-muscarinic M3 receptor heterodimer. The disease relevance of such biological complexity can only be truly demonstrated in fresh human tissue, in an environment where the receptor and pathway interaction occurs naturally.
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