Stemolecule Y27632 Dihydrochloride Hydrate

Catalog 04-0012-H-10
Size 10 mg
Price
$499.00
$499.00
Availability In stock
Catalog
04-0012-H-10

Product Overview

Y27632 is a cell-permeable small molecule Rho-associated kinase (ROCK) inhibitor1. Y27632 has been found to prevent apoptosis as well as enhance the survival and cloning efficiency of dissociated human embryonic stem (ES) cells without affecting their self-renewal properties or pluripotency2. This molecule has also been shown to enhance survival during the transplantation of ES cell-derived neural precursors3. Y27632 in combination with Pifithrin-µ significantly improves cell recovery after cryopreservation4.

 
Also available: Stemolecule Y27632 (04-0012), Stemolecule Y27632 in Solution (04-0012-02)
 
Stemgent conveniently provides all the components comprising the 5i/L/A media supplment necessary to support naive pluripotent stem cell applications.

5i (inhibitors):

L: Stemfactor™ LIF, Human Recombinant (03-0016), and

A: Stemfactor™ Activin A, Human Recombinant (03-0001)


Product Specifications

Product Name
Stemolecule Y27632 Dihydrochloride Hydrate
Catalog Number
04-0012-H-10
Size
10 mg
Alternate Name(s)
(1R,4r)-4-((R)-1-aminoethyl)-N-(pyridine-4-yl)cyclohexanecarboxamide dihydrochloride hydrate
Chemical Formula
C14H21N3O・2HCl・H2O
Molecular Weight
338.27
CAS Number
331752-47-7
Purity
Greater than 98%
Formulation
White to pale yellow crystalline powder
Solubility
Reconstitute in DMSO to the desired concentration. For reconstitution instructions please reference product specifications sheet.
Storage and Stability
Store powder at -20 °C protected from light. Following reconstitution, store aliquots at -20 °C. Stock solutions are stable for 6 months when stored as directed.
Quality Control
The purity of Y27632 was determined by HPLC analysis. Elemental analysis, NMR, mass spectrum: consistent with structure. Cellular toxicity of Y27632 was tested on mouse embryonic stem cells.
Related Products
Y27632 (04-0012)
Y27632 Dihydrochloride Hydrate (04-0012-H-10)

Specification Sheets

Safety Data Sheets

Product Specifications

Product Name
Stemolecule Y27632 Dihydrochloride Hydrate
Catalog Number
04-0012-H-10
Size
10 mg
Alternate Name(s)
(1R,4r)-4-((R)-1-aminoethyl)-N-(pyridine-4-yl)cyclohexanecarboxamide dihydrochloride hydrate
Chemical Formula
C14H21N3O・2HCl・H2O
Molecular Weight
338.27
CAS Number
331752-47-7
Purity
Greater than 98%
Formulation
White to pale yellow crystalline powder
Solubility
Reconstitute in DMSO to the desired concentration. For reconstitution instructions please reference product specifications sheet.
Storage and Stability
Store powder at -20 °C protected from light. Following reconstitution, store aliquots at -20 °C. Stock solutions are stable for 6 months when stored as directed.
Quality Control
The purity of Y27632 was determined by HPLC analysis. Elemental analysis, NMR, mass spectrum: consistent with structure. Cellular toxicity of Y27632 was tested on mouse embryonic stem cells.
Related Products
Y27632 (04-0012)
Y27632 Dihydrochloride Hydrate (04-0012-H-10)

Specification Sheets

Safety Data Sheets