Stemolecule Wnt Inhibitor IWP-4

Catalog 04-0036
Size 2 mg
Price
$99.00
$99.00
Availability In stock
Catalog
04-0036

Product Overview

Wnt Inhibitor IWP-4 was identified in a high throughput screen for antagonists of the Wnt / β-catenin pathway. Wnt Inhibitor IWP-4 prevents palmitylation of Wnt proteins by Porcupine (Porcn), a membrane-bound O-acyltransferase, there by blocking Wnt secretion and activity. It also blocks phosphorylation of the Lrp6 receptor and accumulation of both Dvl2 and β-catenin1.  


Product Specifications

Product Name
Stemolecule Wnt Inhibitor IWP-4
Catalog Number
04-0036
Size
2 mg
Chemical Name
2-(3,4,6,7-tetrahydro-3-(2-methoxyphenyl)-4-oxothieno[3,2-d]pyrimidin-2-ylthio)-N-(6-methylbenzo[d]thiazol-2-yl)acetamide
Chemical Formula
C23H20N4O3S3
Molecular Weight
496.62
CAS Number
686772-17-8
Purity
Greater than 96% by HPLC analysis
Formulation
White solid
Solubility
Wnt Inhibitor IWP-4 molecule is soluble in DMSO at 1.2 mM.
Reconstitution
For a 1.2 mM concentrated stock solution of Wnt Inhibitor IWP-4, reconstitute the compound by adding 3.36 mL of DMSO to the entire contents of the vial. If precipitate is observed, warm the solution to 37 °C for 2 to 5 minutes. For use in cell c
Storage and Stability
Store powder at 4 °C protected from light.
Information about the stability of Stemolecules in solution is largely not available. As a general guideline, we recommend that stock solution be freshly made and stored in aliquots at -20 °C, protected from light. The effect of storage of stock solutions should be verified for each application.
Quality Control
The purity of Wnt Inhibitor IWP-4 was determined by HPLC analysis. The accurate mass was determined by mass spectrometry. No acute cytotoxicity was observed in mouse embryonic stem cells following a 6 hour exposure to 1 nM - 25 µM of Wnt Inhibitor IWP-4 .

Specification Sheets

Safety Data Sheets


References

  1. Chen, B., Dodge, M.E., Tang, W., Lu, J., Ma, Z., Fan, C.W., Wei, S., Hao, W., Kilgore, J., Williams, N.S., Roth, M.G., Amatruda, J.F., Chen, C., and Lum, L. (2009) Small molecule-mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer. Nat Chem Biol 5: 100-107.

Additional Publications

Product Specifications

Product Name
Stemolecule Wnt Inhibitor IWP-4
Catalog Number
04-0036
Size
2 mg
Chemical Name
2-(3,4,6,7-tetrahydro-3-(2-methoxyphenyl)-4-oxothieno[3,2-d]pyrimidin-2-ylthio)-N-(6-methylbenzo[d]thiazol-2-yl)acetamide
Chemical Formula
C23H20N4O3S3
Molecular Weight
496.62
CAS Number
686772-17-8
Purity
Greater than 96% by HPLC analysis
Formulation
White solid
Solubility
Wnt Inhibitor IWP-4 molecule is soluble in DMSO at 1.2 mM.
Reconstitution
For a 1.2 mM concentrated stock solution of Wnt Inhibitor IWP-4, reconstitute the compound by adding 3.36 mL of DMSO to the entire contents of the vial. If precipitate is observed, warm the solution to 37 °C for 2 to 5 minutes. For use in cell c
Storage and Stability
Store powder at 4 °C protected from light.
Information about the stability of Stemolecules in solution is largely not available. As a general guideline, we recommend that stock solution be freshly made and stored in aliquots at -20 °C, protected from light. The effect of storage of stock solutions should be verified for each application.
Quality Control
The purity of Wnt Inhibitor IWP-4 was determined by HPLC analysis. The accurate mass was determined by mass spectrometry. No acute cytotoxicity was observed in mouse embryonic stem cells following a 6 hour exposure to 1 nM - 25 µM of Wnt Inhibitor IWP-4 .

Specification Sheets

Safety Data Sheets

References

  1. Chen, B., Dodge, M.E., Tang, W., Lu, J., Ma, Z., Fan, C.W., Wei, S., Hao, W., Kilgore, J., Williams, N.S., Roth, M.G., Amatruda, J.F., Chen, C., and Lum, L. (2009) Small molecule-mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer. Nat Chem Biol 5: 100-107.

Additional Publications