Stemolecule Wnt Inhibitor IWP-3

Catalog 04-0035
Size 2 mg
Price
$99.00
$99.00
Availability In stock
Catalog
04-0035

Product Overview

Stemolecule Wnt Inhibitor IWP-3 was identified in a high throughput screen for antagonists of the Wnt/β-catenin pathway. Wnt Inhibitor IWP-3 prevents palmitylation of Wnt proteins by Porcupine (Porcn), a membrane-bound O-acyltransferase, thereby blocking Wnt secretion and activity. It also blocks phosphorylation of the Lrp6 receptor and accumulation of both Dvl2 and β-catenin1. The inhibition of the Wnt pathway through the use of IWP-3 has also been shown to promote the formation of cardiocytes from human embryonic stem cell-derived mesoderm cells2


Product Specifications

Product Name
Stemolecule Wnt Inhibitor IWP-3
Catalog Number
04-0035
Size
2 mg
Alternate Name(s)
2-(3-(4-fluorophenyl)-3,4,6,7-tetrahydro-4-oxothieno[3,2-d]pyrimidin-2-ylthio)-N-(6-methylbenzo[d]thiazol-2-yl)acetamide
Chemical Formula
C22H17FN4O2S3
Molecular Weight
484.59
CAS Number
687561-60-0
Purity
Greater than 99% by HPLC analysis
Formulation
Light yellow solid
Solubility
This molecule is soluble in DMSO at 100 mM.
Reconstitution
For a 10 mM concentrated stock solution of Wnt Inhibitor IWP-3, reconstitute the compound by adding 412.7 μL of DMSO to the entire contents of the vial. If precipitate is observed, warm the solution to 37 °C for 2 to 5 minutes. For cell culture,
Storage and Stability
Store powder at 4 °C protected from light.
Information about the stability of Stemolecules in solution is largely not available. As a general guideline, we recommend that stock solution be freshly made and stored in aliquots at -20 °C, protected from light. The effect of storage of stock solutions should be verified for each application.
Quality Control
The purity of Wnt Inhibitor IWP-3 was determined by HPLC analysis. The accurate mass was determined by mass spectrometry. Cellular toxicity of Wnt Inhibitor IWP-3 was tested on mouse embryonic stem cells.

Specification Sheets

Safety Data Sheets


Product Specifications

Product Name
Stemolecule Wnt Inhibitor IWP-3
Catalog Number
04-0035
Size
2 mg
Alternate Name(s)
2-(3-(4-fluorophenyl)-3,4,6,7-tetrahydro-4-oxothieno[3,2-d]pyrimidin-2-ylthio)-N-(6-methylbenzo[d]thiazol-2-yl)acetamide
Chemical Formula
C22H17FN4O2S3
Molecular Weight
484.59
CAS Number
687561-60-0
Purity
Greater than 99% by HPLC analysis
Formulation
Light yellow solid
Solubility
This molecule is soluble in DMSO at 100 mM.
Reconstitution
For a 10 mM concentrated stock solution of Wnt Inhibitor IWP-3, reconstitute the compound by adding 412.7 μL of DMSO to the entire contents of the vial. If precipitate is observed, warm the solution to 37 °C for 2 to 5 minutes. For cell culture,
Storage and Stability
Store powder at 4 °C protected from light.
Information about the stability of Stemolecules in solution is largely not available. As a general guideline, we recommend that stock solution be freshly made and stored in aliquots at -20 °C, protected from light. The effect of storage of stock solutions should be verified for each application.
Quality Control
The purity of Wnt Inhibitor IWP-3 was determined by HPLC analysis. The accurate mass was determined by mass spectrometry. Cellular toxicity of Wnt Inhibitor IWP-3 was tested on mouse embryonic stem cells.

Specification Sheets

Safety Data Sheets