Stemolecule SMO Antagonist

Catalog 04-0031
Size 2 mg
Price
$199.00
$199.00
Availability In stock
Catalog
04-0031

Product Overview

Stemolecule SMO Antagonist (also known as HhAntag) is an analog of SANT-21. SANT-2 was originally identified through a high throughput screen for inhibitors of Sonic hedgehog signaling1 and is structurally distinct from cyclopamine2. Hedgehog signaling is involved in embryogenesis as well as cancer progression3. The mechanism of action was determined to be allosteric inhibition of Smoothened (SMO), an integral membrane protein mediator of Hedgehog signaling4.


Product Specifications

Product Name
Stemolecule SMO Antagonist
Catalog Number
04-0031
Size
2 mg
Alternate Name(s)
HhAntag
N-(4-chloro-3-(6-(dimethylamino)-1H-benzo[d]imidazol-2-yl)-phenyl)-3,5-dimethoxybenzamide
Chemical Formula
C24H23ClN4O3
Molecular Weight
450.92
CAS Number
496794-70-8
Purity
Greater than 95% by HPLC analysis
Formulation
Yellow powder
Solubility
This molecule is soluble in DMSO at 100 mM.
Reconstitution
For a 10 mM stock solution of SMO Antagonist, add 443.5 μL DMSO to the entire contents of the vial. If precipitate is observed, warm the solution to 37 °C for 2 to 5 minutes. For cell culture, the media should be prewarmed prior to adding SMO Antag.
Storage and Stability
Store powder at 4 °C protected from light.
Information about the stability of Stemolecules in solution is largely not available. As a general guideline, we recommend that stock solutions be freshly made and stored in aliquots at -20 °C, protected from light. The effect of storage of stock solutions should be verified for each application.
Quality Control
The purity of SMO Antagonist was determined by HPLC analysis. The accurate mass was determined by mass spectrometry. Cellular toxicity of SMO Antagonist was tested on mouse embryonic stem cells.
Related Products
Stemolecule SHH Antagonist (Cat.No.04-0032)

Specification Sheets

Safety Data Sheets


Product Specifications

Product Name
Stemolecule SMO Antagonist
Catalog Number
04-0031
Size
2 mg
Alternate Name(s)
HhAntag
N-(4-chloro-3-(6-(dimethylamino)-1H-benzo[d]imidazol-2-yl)-phenyl)-3,5-dimethoxybenzamide
Chemical Formula
C24H23ClN4O3
Molecular Weight
450.92
CAS Number
496794-70-8
Purity
Greater than 95% by HPLC analysis
Formulation
Yellow powder
Solubility
This molecule is soluble in DMSO at 100 mM.
Reconstitution
For a 10 mM stock solution of SMO Antagonist, add 443.5 μL DMSO to the entire contents of the vial. If precipitate is observed, warm the solution to 37 °C for 2 to 5 minutes. For cell culture, the media should be prewarmed prior to adding SMO Antag.
Storage and Stability
Store powder at 4 °C protected from light.
Information about the stability of Stemolecules in solution is largely not available. As a general guideline, we recommend that stock solutions be freshly made and stored in aliquots at -20 °C, protected from light. The effect of storage of stock solutions should be verified for each application.
Quality Control
The purity of SMO Antagonist was determined by HPLC analysis. The accurate mass was determined by mass spectrometry. Cellular toxicity of SMO Antagonist was tested on mouse embryonic stem cells.
Related Products
Stemolecule SHH Antagonist (Cat.No.04-0032)

Specification Sheets

Safety Data Sheets