Stemolecule ROCK II Inhibitor

Catalog 04-0030
Size 2 mg
Price
$199.00
$199.00
Availability In stock
Catalog
04-0030

Product Overview

Stemolecule ROCK II Inhibitor (also known as SR 3677) is a specific inhibitor for type 2 Rho-associated, coiled-coil containing protein kinase (ROCK)1. ROCKs are serine/threonine-specific protein kinases which play a crucial role in organization of the actin cytoskeleton2. ROCK inhibitors have been found to prevent apoptosis, as well as enhance the survival and cloning efficiency of dissociated human embryonic stem (ES) cells without affecting their self-renewal properties or pluripotency2,3.


Product Specifications

Product Name
Stemolecule ROCK II Inhibitor
Catalog Number
04-0030
Size
2 mg
Alternate Name(s)
SR 3677
N-(2-(2-(dimethylamino)ethoxy)-4-(1H-pyrazol-4-yl)phenyl)-2,3-dihydrobenzo[b][1,4]dioxine-2-carboxamide SR3677; SR 3677
Chemical Formula
C22H24N4O4
Molecular Weight
408.45
CAS Number
1072959-67-1
Purity
Greater than 98% by HPLC analysis
Formulation
White powder
Solubility
For a 10 mM concentrated stock solution of ROCK II Inhibitor, reconstitute the compound by adding 489.7 µL of DMSO to the entire contents of the vial. If precipitate is observed, warm the solution to 37 °C for 2 to 5 minutes. For cell culture, the media should be prewarmed prior to adding the reconstituted compound. Note: for most cells, the maximum tolerance to DMSO is less than 0.5%. This molecule is soluble in DMSO at 100 mM.
Storage and Stability
Store powder at 4 °C protected from light.
Information about the stability of Stemolecules in solution is largely not available. As a general guideline, we recommend that stock solution be freshly made and stored in aliquots at -20 °C, protected from light. The effect of storage of stock solutions should be verified for each application.
Quality Control
The purity of ROCK II Inhibitor was determined by HPLC analysis. The accurate mass was determined by mass spectrometry. Cellular toxicity of ROCK II Inhibitor was tested on mouse embryonic stem cells.

Specification Sheets

Safety Data Sheets


Product Specifications

Product Name
Stemolecule ROCK II Inhibitor
Catalog Number
04-0030
Size
2 mg
Alternate Name(s)
SR 3677
N-(2-(2-(dimethylamino)ethoxy)-4-(1H-pyrazol-4-yl)phenyl)-2,3-dihydrobenzo[b][1,4]dioxine-2-carboxamide SR3677; SR 3677
Chemical Formula
C22H24N4O4
Molecular Weight
408.45
CAS Number
1072959-67-1
Purity
Greater than 98% by HPLC analysis
Formulation
White powder
Solubility
For a 10 mM concentrated stock solution of ROCK II Inhibitor, reconstitute the compound by adding 489.7 µL of DMSO to the entire contents of the vial. If precipitate is observed, warm the solution to 37 °C for 2 to 5 minutes. For cell culture, the media should be prewarmed prior to adding the reconstituted compound. Note: for most cells, the maximum tolerance to DMSO is less than 0.5%. This molecule is soluble in DMSO at 100 mM.
Storage and Stability
Store powder at 4 °C protected from light.
Information about the stability of Stemolecules in solution is largely not available. As a general guideline, we recommend that stock solution be freshly made and stored in aliquots at -20 °C, protected from light. The effect of storage of stock solutions should be verified for each application.
Quality Control
The purity of ROCK II Inhibitor was determined by HPLC analysis. The accurate mass was determined by mass spectrometry. Cellular toxicity of ROCK II Inhibitor was tested on mouse embryonic stem cells.

Specification Sheets

Safety Data Sheets