Stemolecule R(+)Bay K 8644

Catalog 04-0013
Size 5 mg
Price
$119.00
$119.00
Availability In stock
Catalog
04-0013

Product Overview

Stemolecule R(+)Bay K 8644 is an L-type Ca2+ channel activator1,2. This molecule has recently been demonstrated to enhance reprogramming efficiency. When only two transcription factors (Oct4 and Klf4) are introduced into mouse embryonic fibroblasts (MEFs), and when used in combination with a histone methyltransferase G9a inhibitor BIX01294, R(+)Bay K 8644 enhances the efficiency of  iPS cell generation significantly3.


Product Specifications

Product Name
Stemolecule R(+)Bay K 8644
Catalog Number
04-0013
Size
5 mg
Alternate Name(s)
(4R)-1,4-dihydro-2,6-dimethyl-5-nitro-4-[2-trifluoromethyl)phenyl]-3-pyridinecarboxylic acid methyl ester
Chemical Formula
C16H15F3N2O4·½H2O
Molecular Weight
356.31
CAS Number
98791-67-4
Purity
Greater than 99% by HPLC analysis
Formulation
Yellow solid
Solubility
For a 10 mM concentrated stock solution of R(+)Bay K 8644, reconstitute the compound by adding 1.4 mL of DMSO to the entire contents of the vial. If precipitate is observed, warm the solution to 37 °C for 2 to 5 minutes. For cell culture, the media should be prewarmed prior to adding the reconstituted compound. Note: for most cells, the maximum tolerance to DMSO is less than 0.5%. This molecule is soluble in DMSO at 100 mM.
Storage and Stability
Store powder at 4 °C protected from light
Information about the stability of Stemolecules in solution is largely not available. As a general guideline, we recommend that stock solution be freshly made and stored in aliquots at -20 °C, protected from light. The effect of storage of stock solutions should be verified for each application.
Quality Control
The purity of R(+)Bay K 8644 was determined by HPLC analysis. The accurate mass was determined by mass spectrometry. Cellular toxicity of R(+)Bay K 8644 was tested on mouse embryonic stem cells.
Related Products
Stemolecule BIX01294 (Cat.No.04-0002)

Specification Sheets

Safety Data Sheets


Product Specifications

Product Name
Stemolecule R(+)Bay K 8644
Catalog Number
04-0013
Size
5 mg
Alternate Name(s)
(4R)-1,4-dihydro-2,6-dimethyl-5-nitro-4-[2-trifluoromethyl)phenyl]-3-pyridinecarboxylic acid methyl ester
Chemical Formula
C16H15F3N2O4·½H2O
Molecular Weight
356.31
CAS Number
98791-67-4
Purity
Greater than 99% by HPLC analysis
Formulation
Yellow solid
Solubility
For a 10 mM concentrated stock solution of R(+)Bay K 8644, reconstitute the compound by adding 1.4 mL of DMSO to the entire contents of the vial. If precipitate is observed, warm the solution to 37 °C for 2 to 5 minutes. For cell culture, the media should be prewarmed prior to adding the reconstituted compound. Note: for most cells, the maximum tolerance to DMSO is less than 0.5%. This molecule is soluble in DMSO at 100 mM.
Storage and Stability
Store powder at 4 °C protected from light
Information about the stability of Stemolecules in solution is largely not available. As a general guideline, we recommend that stock solution be freshly made and stored in aliquots at -20 °C, protected from light. The effect of storage of stock solutions should be verified for each application.
Quality Control
The purity of R(+)Bay K 8644 was determined by HPLC analysis. The accurate mass was determined by mass spectrometry. Cellular toxicity of R(+)Bay K 8644 was tested on mouse embryonic stem cells.
Related Products
Stemolecule BIX01294 (Cat.No.04-0002)

Specification Sheets

Safety Data Sheets