Differentiation

REPROCELL Discovery - iPS Services

Cell Differentiation Services

Creating Custom Cells

REPROCELL has been differentiating iPS cells for over 15 years, and becoming one of the first companies to offer differentiated cell types as commercially available consumable products. We have extensive experience with hepatocytes, cardiomyocytes and neuronal cells. REPROCELL also has collaborations with key academic labs and ongoing projects related to several other differentiated cell types.

Through our custom reprogramming services we have the capability to generate iPS cells from patient material, either normal or diseased. These iPSC can be used to create model cells useful for organ regeneration studies or disease model cells for use in drug discovery and basic research. And if you need help acquiring clinical material, we can source blood, urine or other tissues through our BioServe tissue network to get you started. Talk to us anytime about a custom project that saves you time and money. REPROCELL has extensive experience in reprogramming and cell differentiation from iPSC.

 

Cardiomyocyte Custom Cells

REPROCELL launched its first commercial cardiomyocyte product, ReproCardio, in 2009. Our current ReproCardio technology does not employ any genetic engineering or artificial selection. As a consequence, the cells are more natural than most competitors and the purity can reach about 60-75%. This is sufficient for sheet contractility and nearly 100% beating of spheroid format aggregates. The residual cardio-fibroblast-like cells actually add stability and structure which is arguably more similar to the authentic in vivo environment. Below are shown some ReproCardio cells stained with various cardiomyocyte lineage markers. If you have a special iPSC strain and need cardiomyocytes, we can customize a project for you to supply differentiated cardiomyocytes that meet your needs. Also, through our BioServe tissue network, we can help you source specific disease states of particular interest for custom reprogramming and cardiomyocyte differentiation.

ReproCardio images

Neurocyte Custom Cells

REPROCELL launched its first commercial neurons, ReproNeuro, in 2010. Our current ReproNeuro product is a mixed population of neurons that mature in culture establishing synaptic connections and even displaying synchronous action potential activations after several weeks when cultured in ReproNeuro MQ medium. REPROCELL has the technical know-how to prepare specially enriched populations as well such as enriched dopaminergic populations or even brain domain-specific populations. Our catalog products include Alzheimer disease cells as well. If you have a special iPSC strain and need neuronal cells, we can customize a project for you to supply differentiated neurocytes that meet your needs. Also, through our BioServe tissue network, we can help you source specific neurodegenerative disease states of particular interest for custom reprogramming and differentiation.

ReproNeuro images

Hepatocyte Custom Cells

REPROCELL launched its first commercial hepatocytes, ReproHepato, in 2012. Our current ReproHepato product is a highly mature population that robustly expresses P450 enzymes and transporters. Unlike primary cell products, iPSC-derived hepatocytes are more long-lived and stable in enzyme expression, and display high consistency due to their clonal nature. If you have a special iPSC strain and need hepatocyte cells, we can customize a project for you to supply differentiated hepatocytes that meet your needs. Also, through our BioServe tissue network, we can help you source specific disease states of particular interest for custom reprogramming and differentiation.

ReproHepato images

Other Custom Cells

Whether your need is for any of the cell types described above or others not listed, REPROCELL may have the know-how or and expert connections to assist you. We’ve had multiple successful experiences with diverse custom projects for Pharma clients in the past. It is possible to use customer proprietary protocols or even to adapt and design new protocols. REPROCELL can also call upon assistance from confidentiality-bound collaborators and scientific consultants. All projects are worth exploring. And since our service pricing and terms are milestone-based, you be assured of fair value. Talk to us anytime about your custom cell needs; talk to the experts!