Predictive Drug Discovery Services
Normally used to confirm the absence of off-target effects or prevent dilemmas caused by species variation, human vascular tissues are frequently available. Vascular tissue can be secured from both healthy donors and donors with a range of diseases including diabetes, hypertension and atherosclerosis.
Biopta can obtain a wide range of blood vessels and our scientists are experts in the dedicated dissection procedures required to isolate functional arteries and veins such as: subcutaneous resistance arteries, mesenteric arteries, coronary arteries, pulmonary arteries and large muscular or conduit arteries such as aorta, tibial artery or saphenous vein.
Biopta utilise a range of techniques including tissue baths (organ baths), wire myographs (small vessel myographs) and perfusion myographs (Biopta’s patented PM-1 technology).
Your test compounds can be assessed for either safety/adverse effects or efficacy on arteries and veins of various sizes; effects of blood pressure treatments can be assessed in resistance arteries; vasoconstriction and vasodilatation can be assessed in coronary and muscular arteries.
As part of our GLP vascular safety offering Biopta can screen for common observations as detailed in the table below.
|Tissue Type||Common Observation|
|Small resistance arteries||Vasoconstriction/vasodilatation; changes in peripheral vascular resistance (indicates potential to alter blood pressure); vascular permeability (leakage)|
|Large conducting arteries||Vascular compliance|
Studies are validated with a variety of reference compounds and examples can be viewed by accessing our on-line catalogue of human assays – industry’s first and only catalogue of human functional tissue pharmacology assays.
Make an inquiry to discuss a customised protocol with one of our expert scientists.