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Stemolecule™ Wnt Inhibitor IWP-2

04-0034

Brand: Stemolecule

Wnt Inhibitor IWP-2 prevents palmitylation of Wnt proteins by Porcupine (Porcn), a membrane-bound O-acyltransferase, thereby blocking Wnt secretion and activity. It also blocks phosphorylation of the Lrp6 receptor and accumulation of both Dvl2 and ?-catenin.

CAS Number: 686770-61-6
Alternate Name(s):
  • N-(6-Methyl-2-benzothiazolyl)-2-[(3,4,6,7-tetrahydro-4-oxo-3-phenylthieno[3,2 d]pyrimidin-2-yl)thio]-acetamide

Currency: 

Product name Product code Pack size Price (USD) Price (GBP) Price (EUR)
Stemolecule™ Wnt Inhibitor IWP-2 04-0034 2 mg $ 120.00 £ 99.00 € 115.00

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Product Information

Stemolecule Wnt Inhibitor IWP-2 was identified in a high throughput screen for antagonists of the Wnt/β-catenin pathway. Wnt Inhibitor IWP-2 prevents palmitylation of Wnt proteins by Porcupine (Porcn), a membrane-bound O-acyltransferase, thereby blocking Wnt secretion and activity. It also blocks phosphorylation of the Lrp6 receptor and accumulation of both Dvl2 and β-catenin1.


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Stemgent and the Stemolecule brand name are trademarks of REPROCELL Inc., Japan.

Product Name: Stemolecule Wnt Inhibitor IWP-2

Catalog Number: 04-0034

Size: 2 mg

Alternate Name(s): N-(6-Methyl-2-benzothiazolyl)-2-[(3,4,6,7-tetrahydro-4-oxo-3-phenylthieno[3,2 d]pyrimidin-2-yl)thio]-acetamide

Chemical Formula: C22H18N4O2S3

Molecular Weight: 466.6

CAS Number: 686770-61-6

Purity: Greater than 99 % by HPLC analysis

Formulation: White powder

Solubility: This molecule is reported to be soluble in DMSO at 5 mM.

Reconstitution: For a 5 mM concentrated stock solution of Wnt Inhibitor IWP-2, reconstitute the compound by adding 857.3 µL of DMSO to the entire contents of the vial. If precipitate is observed, warm the solution to 37°C for 2 to 5 minutes.  For cell culture, the media should be prewarmed prior to adding the reconstituted compound. Note: for most cells, the maximum tolerance to DMSO is less than 0.5%. 

Storage and Stability: Store powder at 4 °C protected from light. Information about the stability of Stemolecules in solution is largely not available. As a general guideline, we recommend that stock solution be freshly made and stored in aliquots at −20 °C, protected from light. The effect of storage of stock solutions should be verified for each application.

Quality Control: The purity of Wnt Inhibitor IWP-2 was determined by HPLC analysis. The accurate mass was determined by mass spectrometry. Cellular toxicity of Wnt Inhibitor IWP-2 was tested on mouse embryonic stem cells.

Specification Sheets:

Safety Data Sheets:

  1. Chen, B., Dodge, M.E., Tang, W., Lu, J., Ma, Z., Fan, C.W., Wei, S., Hao, W., Kilgore, J., Williams, N.S., Roth, M.G., Amatruda, J.F., Chen, C., and Lum, L. Small molecule-mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer. Nat Chem Biol 5: 100-107 (2009).

Additional Publications