Lead Identification in Human-Relevant 3D Models and iPSCs

REPROCELL offers services and products to support your lead identification programmes. We can custom-create human-relevant 3D models using iPSCs, which when combined with our 96 well Alvetex cell culture plates allows lead identification to be conducted at high-throughput in phenotypically-relevant models.

Scanning electron microscope image of Alvetex Scaffold

96 well plate format available for high throughput assays

Co-culture of primary keratinocytes and primary dermal fibroblasts forming a full-thickness human skin construct

Triple fluorescent staining of HepG2 cells grown in 3D on Alvetex Scaffold

Alvetex Delivers More In Vivo-like Results

3D cell cultures using REPROCELL's Alvetex technology deliver more in vivo-like results than traditional 2D monolayer cultures.

• Highly porous inert scaffold made from cross-linked polystyrene (200 μm thick).
• Suitable for a wide range of cell types including primary or iPSC-derived cells from most organs, various stem cells, cancer, and complex co-culture models.
• Automation – 96 well plate formats compatible with high throughput screening and a variety of assays and techniques.
• Build more predictive biological models by maintaining in vivo physiological properties, enhancing cell viability and longevity.
• Simple histology, imaging and RNA/protein isolation analysis endpoints.
• Add perfusion in 3D for another step closer to in vivo.

Alvetex 3D Cell Culture Models

3D cell cultures using REPROCELL’s Alvetex technology deliver more in vivo-like results than traditional 2D monolayer cultures.

• Highly porous inert scaffold made from cross-linked polystyrene (200 μm thick).
• Suitable for a wide range of cell types including primary or iPSC-derived cells from most organs, various stem cells, cancer, and complex co-culture models.
• Automation – 96 well and 384 well plate formats compatible with high throughput screening and a variety of assays and techniques.
• Build more predictive biological models by maintaining in vivo physiological properties, enhancing cell viability and longevity.
• Simple histology, imaging and RNA/ protein isolation analysis endpoints.
• Add perfusion in 3D for another step closer to in vivo.