Drug Discovery Assays Catalog
Filter by:

Assay Type

Tissue

Target

Control Compound

Study Type

Functional Endpoint

Make an inquiry

Drug Discovery Assay Catalog

Available Assays:
 

Vasoconstriction in human coronary arteries (5-HT receptor – 5-HT)

Reference number: B003

Assay type: Blood Vessels
Tissue: Human Coronary Artery (Healthy)
Target: 5-HT receptor
Control Compound: 5-HT
Study Type: Wire Myography
Functional Endpoint: Vasoconstriction

View assay →

 

Vasoconstriction in human coronary arteries (Opioid and opioid-like receptors)

Reference number: B004

Assay type: Blood Vessels
Tissue: Human Coronary Artery (Healthy)
Target: Opioid & opioid-like receptors
Control Compound: Mephedrone
Study Type: Wire Myography
Functional Endpoint: Vasoconstriction

View assay →

 

Vasoconstriction in human coronary arteries (Angiotensin receptor)

Reference number: B007

Assay type: Blood Vessels
Tissue: Human Coronary Artery (Healthy)
Target: Angiotensin receptor
Control Compound: Angiotensin II
Study Type: Organ bath
Functional Endpoint: Vasoconstriction

View assay →

 

Vasoconstriction in human coronary arteries (Vasopressin & oxytocin receptors)

Reference number: B008

Assay type: Blood Vessels
Tissue: Human Coronary Artery (Healthy)
Target: Vasopressin & oxytocin receptors
Control Compound: 8-arginine vasopressin
Study Type: Organ bath
Functional Endpoint: Vasoconstriction

View assay →

 

Vasodilatation in human chorionic plate arteries (PDE5)

Reference number: B009

Assay type: Blood Vessels
Tissue: Human Chorionic Plate Arteries (Pre-Eclamptic)
Target: PDE5
Control Compound: Sildenafil
Study Type: Wire Myography
Functional Endpoint: Vasodilatation

View assay →

 

Vasodilatation in human chorionic plate arteries (Bradykinin receptor)

Reference number: B010

Assay type: Blood Vessels
Tissue: Human Chorionic Plate Arteries (Healthy)
Target: Bradykinin receptor
Control Compound: Bradykinin
Study Type: Wire Myography
Functional Endpoint: Vasodilatation

View assay →

 

Vasodilatation in human pre-eclamptic chorionic plate arteries (PDE5)

Reference number: B011

Assay type: Blood Vessels
Tissue: Human Chorionic Plate Arteries (Pre-Eclamptic)
Target: PDE5
Control Compound: Sildenafil
Study Type: Wire Myography
Functional Endpoint: Vasodilatation

View assay →

 

Vasodilatation in human pre-eclamptic chorionic plate arteries (Bradykinin receptor)

Reference number: B012

Assay type: Blood Vessels
Tissue: Human Chorionic Plate Arteries (Pre-Eclamptic)
Target: Bradykinin receptor
Control Compound: Bradykinin
Study Type: Wire Myography
Functional Endpoint: Vasodilatation

View assay →

 

Vasodilatation in human subcutaneous resistance arteries (Acetylcholine receptor)

Reference number: B016

Assay type: Blood Vessels
Tissue: Human Subcutaneous Resistance Artery (Healthy)
Target: Acetylcholine receptor
Control Compound: Acetylcholine
Study Type: Wire Myography
Functional Endpoint: Vasodilatation

View assay →

 

Vasodilatation in human subcutaneous resistance arteries (Vasopressin & oxytocin receptors)

Reference number: B017

Assay type: Blood Vessels
Tissue: Human Subcutaneous Resistance Artery (Healthy)
Target: Vasopressin & oxytocin receptors
Control Compound: Desmopressin
Study Type: Wire Myography
Functional Endpoint: Vasodilatation

View assay →

 

Vasodilatation in human subcutaneous resistance arteries (Nitric oxide donor)

Reference number: B019

Assay type: Blood Vessels
Tissue: Human Subcutaneous Resistance Artery (Healthy)
Target: Nitric oxide donor
Control Compound: SNP
Study Type: Wire Myography
Functional Endpoint: Vasodilatation

View assay →

 

Vasoconstriction in human subcutaneous resistance arteries (Adrenoceptor)

Reference number: B020

Assay type: Blood Vessels
Tissue: Human Subcutaneous Resistance Artery (Healthy)
Target: Adrenoceptor
Control Compound: Phenylephrine
Study Type: Wire Myography
Functional Endpoint: Vasodilatation

View assay →

 

Vasoconstriction in human subcutaneous resistance arteries (Prostanoid receptor)

Reference number: B021

Assay type: Blood Vessels
Tissue: Human Subcutaneous Resistance Artery (Healthy)
Target: Prostanoid receptor
Control Compound: U46619
Study Type: Wire Myography
Functional Endpoint: Vasoconstriction

View assay →

 

Vasodilatation in ischaemic human subcutaneous resistance arteries (Bradykinin receptor)

Reference number: B022

Assay type: Blood Vessels
Tissue: Human Subcutaneous Resistance Artery (Ischaemic)
Target: Bradykinin receptor
Control Compound: Bradykinin
Study Type: Wire Myography
Functional Endpoint: Vasodilatation

View assay →

 

Vasoconstriction in human saphenous vein (5-HT receptor)

Reference number: B023

Assay type: Blood Vessels
Tissue: Human Saphenous Vein (Healthy)
Target: 5-HT receptor
Control Compound: Sumatriptan
Study Type: Wire Myography
Functional Endpoint: Vasoconstriction

View assay →

 

Vasoconstriction in human coronary arteries (5-HT receptor – Sumatriptan)

Reference number: B028

Assay type: Blood Vessels
Tissue: Human Coronary Artery (Healthy)
Target: 5-HT receptor
Control Compound: Sumatriptan
Study Type: Wire Myography
Functional Endpoint: Vasoconstriction

View assay →

 

Vasoconstriction in denuded human coronary arteries (5-HT receptor)

Reference number: B030

Assay type: Blood Vessels
Tissue: Human Coronary Artery (Healthy – Denuded)
Target: 5-HT receptor
Control Compound: 5-HT
Study Type: Organ bath
Functional Endpoint: Vasoconstriction

View assay →

 

Vasodilatation in human subcutaneous resistance arteries (PDE3 receptor)

Reference number: B034

Assay type: Blood Vessels
Tissue: Human Subcutaneous Resistance Artery (Healthy)
Target: PDE3
Control Compound: Milrinone
Study Type: Wire Myography
Functional Endpoint: Vasodilatation

View assay →

 

Vasodilatation in human subcutaneous resistance arteries (Bradykinin receptor)

Reference number: B035

Assay type: Blood Vessels
Tissue: Human Subcutaneous Resistance Artery (Healthy)
Target: Bradykinin receptor
Control Compound: Bradykinin
Study Type: Wire Myography
Functional Endpoint: Vasodilatation

View assay →

 

Vascular permeability in human subcutaneous resistance arteries (PAR-1, PAR-3 and PAR-4 receptors)

Reference number: B036

Assay type: Blood Vessels
Tissue: Human Subcutaneous Resistance Artery (Healthy)
Target: PAR-1, PAR-3 and PAR-4 receptors
Control Compound: Thrombin
Study Type: Perfusion myography
Functional Endpoint: Vascular permeability

View assay →

 

Vasoconstriction in atherosclerotic human subcutaneous resistance arteries (Angiotensin receptor)

Reference number: B037

Assay type: Blood Vessels
Tissue: Human Resistance Artery (Atherosclerotic)
Target: Angiotensin receptor
Control Compound: PDA-angiotensin 1
Study Type: Wire Myography
Functional Endpoint: Vasoconstriction

View assay →

 

Vasodilatation in ischaemic human subcutaneous resistance arteries (Nitric oxide donor)

Reference number: B038

Assay type: Blood Vessels
Tissue: Human Subcutaneous Resistance Artery (Ischaemic)
Target: Nitric oxide donor
Control Compound: SNP
Study Type: Wire Myography
Functional Endpoint: Vasodilatation

View assay →

 

Vasodilatation in human skeletal muscle arteries (Acetycholine receptor)

Reference number: B039

Assay type: Blood Vessels
Tissue: Human Skeletal Muscle Artery (Healthy)
Target: Acetylcholine receptor
Control Compound: Acetylcholine
Study Type: Wire Myography
Functional Endpoint: Vasodilatation

View assay →

 

Vasodilatation in human skeletal muscle arteries (Nitric oxide donor)

Reference number: B040

Assay type: Blood Vessels
Tissue: Human Skeletal Muscle Artery (Healthy)
Target: Nitric oxide donor
Control Compound: SNP
Study Type: Wire Myography
Functional Endpoint: Vasodilatation

View assay →

 

Contractile force in electrically stimulated human atrial pectinate muscle (Adrenoceptors – Isoprenaline)

Reference number: B043

Assay type: Cardiac Muscle
Tissue: Human Atrial Pectinate Muscle (Healthy)
Target: Adrenoceptor
Control Compound: Isoprenaline
Study Type: EFS organ bath
Functional Endpoint: Contractile force

View assay →

 

Contractile force in electrically stimulated human ventricular trabeculae muscle (5-HT receptor)

Reference number: B047

Assay type: Cardiac Muscle
Tissue: Human Ventricular Trabeculae Muscle (Healthy)
Target: 5-HT receptor
Control Compound: 5-HT
Study Type: EFS organ bath
Functional Endpoint: Contractile force

View assay →

 

Contractile force in electrically stimulated human atrial pectinate muscle (5-HT receptor)

Reference number: B048

Assay type: Cardiac Muscle
Tissue: Human Atrial Pectinate Muscle (Healthy)
Target: 5-HT receptor
Control Compound: 5-HT
Study Type: EFS organ bath
Functional Endpoint: Contractile force

View assay →

 

Contractile force in electrically stimulated human atrial pectinate muscle (Adrenoceptors – Salbutamol)

Reference number: B049

Assay type: Cardiac Muscle
Tissue: Human Atrial Pectinate Muscle (Healthy)
Target: Adrenoceptor
Control Compound: Salbutamol
Study Type: EFS organ bath
Functional Endpoint: Contractile force

View assay →

 

Contractile force in electrically stimulated human atrial pectinate muscle (PDE3 receptor)

Reference number: B050

Assay type: Cardiac Muscle
Tissue: Human Atrial Pectinate Muscle (Healthy)
Target: PDE3
Control Compound: Milrinone
Study Type: EFS organ bath
Functional Endpoint: Contractile force

View assay →

 

Bronchodilatation in secondary healthy human airways (Adrenoceptor – Isoprenaline)

Reference number: B052

Assay type: Respiratory
Tissue: Human Tertiary Or Lower Airways (Healthy)
Target: Adrenoceptor
Control Compound: Isoprenaline
Study Type: Wire Myography
Functional Endpoint: Bronchodilatation

View assay →

 

Bronchoconstriction in secondary asthmatic human airways (Acetylcholine receptor)

Reference number: B053

Assay type: Respiratory
Tissue: Human Secondary Airways (Asthmatic)
Target: Acetylcholine receptor
Control Compound: Carbachol
Study Type: Organ bath
Functional Endpoint: Bronchoconstriction

View assay →

 

Bronchodilatation in secondary asthmatic human airways (Adrenoceptor)

Reference number: B054

Assay type: Respiratory
Tissue: Human Secondary Airways (Asthmatic)
Target: Adrenoceptor
Control Compound: Salbutamol
Study Type: Organ bath
Functional Endpoint: Bronchodilatation

View assay →

 

Bronchoconstriction in tertiary or lower healthy human airways (Prostanoid receptor)

Reference number: B055

Assay type: Respiratory
Tissue: Human Tertiary Or Lower Airways (Healthy)
Target: Prostanoid receptor
Control Compound: U46619
Study Type: Wire Myography
Functional Endpoint: Bronchoconstriction

View assay →

 

Bronchodilatation in tertiary or lower healthy human airways (Adrenoceptor – Salbutamol)

Reference number: B056

Assay type: Respiratory
Tissue: Human Tertiary Or Lower Airways (Healthy)
Target: Adrenoceptor
Control Compound: Salbutamol
Study Type: Wire Myography
Functional Endpoint: Bronchodilatation

View assay →

 

Bronchoconstriction in tertiary or lower healthy human airways (Acetylcholine receptor)

Reference number: B057

Assay type: Respiratory
Tissue: Human Tertiary Or Lower Airways (Healthy)
Target: Acetylcholine receptor
Control Compound: Acetylcholine
Study Type: Wire Myography
Functional Endpoint: Bronchoconstriction

View assay →

 

Bronchodilatation in tertiary or lower healthy human airways (Adrenoceptor – Isoprenaline)

Reference number: B058

Assay type: Respiratory
Tissue: Human Tertiary Or Lower Airways (Healthy)
Target: Adrenoceptor
Control Compound: Isoprenaline
Study Type: Wire Myography
Functional Endpoint: Bronchodilatation

View assay →

 

Bronchodilatation in secondary COPD human airways (Adrenoceptor)

Reference number: B059

Assay type: Respiratory
Tissue: Human Tertiary Or Lower Airways (COPD)
Target: Adrenoceptor
Control Compound: Isoprenaline
Study Type: Wire Myography
Functional Endpoint: Bronchodilatation

View assay →

 

Bronchoconstriction in denuded secondary healthy human airways (Acetylcholine receptor)

Reference number: B060

Assay type: Respiratory
Tissue: Human Secondary Airways (Healthy – Denuded)
Target: Acetylcholine receptor
Control Compound: Carbachol
Study Type: Organ bath
Functional Endpoint: Bronchoconstriction

View assay →

 

Bronchoconstriction in denuded secondary healthy human airways (Histamine receptor)

Reference number: B061

Assay type: Respiratory
Tissue: Human Secondary Airways (Healthy – Denuded)
Target: Histamine receptor
Control Compound: Histamine
Study Type: Organ bath
Functional Endpoint: Bronchoconstriction

View assay →

 

Ion channel function in healthy human tracheal mucosa (Adrenoceptors)

Reference number: B062

Assay type: Respiratory
Tissue: Human Trachea (Mucosa) (Healthy)
Target: Adrenoceptor
Control Compound: Isoprenaline
Study Type: Ussing chamber
Functional Endpoint: Ion channel function

View assay →

 

Ion channel function in healthy human tracheal mucosa (Sodium channels)

Reference number: B063

Assay type: Respiratory
Tissue: Human Trachea (Mucosa) (Healthy)
Target: Sodium channels
Control Compound: Amiloride
Study Type: Ussing chamber
Functional Endpoint: Ion channel function

View assay →

 

Bronchodilatation in tertiary or lower human airways (Adrenoceptors – Formoterol)

Reference number: B065

Assay type: Respiratory
Tissue: Human Tertiary Or Lower Airways (Healthy)
Target: Adrenoceptor
Control Compound: Formoterol
Study Type: Wire Myography
Functional Endpoint: Bronchodilatation

View assay →

 

Bronchodilatation in tertiary or lower human airways (Adrenoceptors – Salbutamol)

Reference number: B066

Assay type: Respiratory
Tissue: Human Tertiary Or Lower Airways (Healthy)
Target:  
Control Compound: Salbutamol
Study Type: Wire Myography
Functional Endpoint: Bronchodilatation

View assay →

 

Bronchodilatation in tertiary or lower asthmatic human airways (Adrenoceptor – Formoterol)

Reference number: B067

Assay type: Respiratory
Tissue: Human Tertiary Or Lower Airways (Asthmatic)
Target: Adrenoceptor
Control Compound: Formoterol
Study Type: Wire Myography
Functional Endpoint: Bronchodilatation

View assay →

 

Bronchodilatation in tertiary or lower asthmatic human airways (Adrenoceptor – Salbutamol)

Reference number: B068

Assay type: Respiratory
Tissue: Human Tertiary Or Lower Airways (Asthmatic)
Target: Adrenoceptor
Control Compound: Salbutamol
Study Type: Wire Myography
Functional Endpoint: Bronchodilatation

View assay →

 

Bronchodilatation in tertiary or lower asthmatic human airways (Adrenoceptor – Salmeterol)

Reference number: B069

Assay type: Respiratory
Tissue: Human Tertiary Or Lower Airways (Asthmatic)
Target: Adrenoceptor
Control Compound: Salmeterol
Study Type: Wire Myography
Functional Endpoint: Bronchodilatation

View assay →

 

Relaxation in human bladder (Adrenoceptor – Isoproterenol)

Reference number: B070

Assay type: GU
Tissue: Human Bladder (Healthy)
Target: Adrenoceptor
Control Compound: Isoproterenol
Study Type: Organ bath
Functional Endpoint: Relaxation

View assay →

 

Relaxation in human ureter (Adrenoceptor – Isoprenaline)

Reference number: B071

Assay type: GU
Tissue: Human Ureter (Healthy)
Target: Adrenoceptor
Control Compound: Isoprenaline
Study Type: Organ bath
Functional Endpoint: Relaxation

View assay →

 

Contraction in human urethra (Adrenoceptor – Phenylephrine)

Reference number: B072

Assay type: GU
Tissue: Human Urethra (Healthy)
Target: Adrenoceptor
Control Compound: Phenylephrine
Study Type: Organ bath
Functional Endpoint: Contraction

View assay →

 

Contraction in human uterus (Vasopressin & Oxytocin Receptor – Oxytocin)

Reference number: B078

Assay type: GU
Tissue: Human Uterus (Healthy)
Target: Vasopressin & oxytocin receptors
Control Compound: Oxytocin
Study Type: Organ bath
Functional Endpoint: Contraction

View assay →

 

Contraction in human uterus (Vasopressin & Oxytocin Receptor – Vasopressin)

Reference number: B079

Assay type: GU
Tissue: Human Uterus (Healthy)
Target: Vasopressin & oxytocin receptors
Control Compound: Vasopressin
Study Type: Organ bath
Functional Endpoint: Contraction

View assay →

 

Relaxation in human uterus (Nitric Oxide Donor)

Reference number: B081

Assay type: GU
Tissue: Human Uterus (Healthy)
Target: Nitric oxide donor
Control Compound: SNP
Study Type: Organ bath
Functional Endpoint: Relaxation

View assay →

 

Relaxation in human uterus (Adrenoceptor – Isoprenaline)

Reference number: B082

Assay type: GU
Tissue: Human Uterus (Healthy)
Target: Adrenoceptor
Control Compound: Isoprenaline
Study Type: Organ bath
Functional Endpoint: Relaxation

View assay →

 

Relaxation in human uterus (Calcium Channels)

Reference number: B083

Assay type: GU
Tissue: Human Uterus (Healthy)
Target: Calcium channels
Control Compound: Isradipine
Study Type: Organ bath
Functional Endpoint: Relaxation

View assay →

 

Contractile force in electrically stimulated human colon (Acetylcholine Esterase)

Reference number: B086

Assay type: GI Tract
Tissue: Human Stomach (Healthy)
Target: Acetylcholine esterase
Control Compound: Galantamine
Study Type: EFS organ bath
Functional Endpoint: Contractile force

View assay →

 

Contractile force in electrically stimulated human colon (Opioid & Opioid like receptors)

Reference number: B087

Assay type: GI Tract
Tissue: Human Colon
Target: Opioid & opioid-like receptors
Control Compound: Meptazinol
Study Type: EFS organ bath
Functional Endpoint: Contractile force

View assay →

 

Contractile force in electrically stimulated human stomach (Motilin receptor)

Reference number: B092

Assay type: GI Tract
Tissue: Human Stomach (Healthy)
Target: Motilin receptor
Control Compound: Erythromycin
Study Type: EFS organ bath
Functional Endpoint: Contractile force

View assay →

 

Permeability in healthy human gastrointestinal mucosa

Reference number: B093

Assay type: GI Tract
Tissue: Human Gastrointestinal Mucosa
Target: N/A
Control Compound: Multiple
Study Type: Ussing chamber
Functional Endpoint: Permeability

View assay →

 

Ion channel function in isolated healthy human gastrointestinal mucosa (Chloride channels)

Reference number: B094

Assay type: GI Tract
Tissue: Human Gastrointestinal Mucosa (Healthy)
Target: Chloride channels
Control Compound: Cholera toxin
Study Type: Ussing chamber
Functional Endpoint: Ion channel function

View assay →

 

Contractile force in electrically stimulated human ventricular trabeculae muscle (adrenoceptor)

Reference number: B095

Assay type: Cardiac Muscle
Tissue: Human Ventricular Trabeculae Muscle (Healthy)
Target: Adrenoceptor
Control Compound: Isoprenaline
Study Type: EFS organ bath
Functional Endpoint: Contractile force

View assay →

 

Contractile force in eletrically stimulated human ventricular trabeculae muscle (acetylcholine receptor)

Reference number: B096

Assay type: Cardiac Muscle
Tissue: Human Ventricular Trabeculae Muscle (Healthy)
Target: Acetylcholine receptor
Control Compound: Acetylcholine
Study Type: EFS organ bath
Functional Endpoint: Contractile force

View assay →

 

Vasoconstriction in human subcutaneous resistance arteries (5-HT receptor)

Reference number: B097

Assay type: Blood Vessels
Tissue: Human Subcutaneous Resistance Artery (Healthy)
Target: 5-HT receptor
Control Compound: 5-HT
Study Type: Wire Myography
Functional Endpoint: Vasoconstriction

View assay →

 

Bronchodilatation in healthy human secondary airways (VIP & PACAP receptors)

Reference number: B098

Assay type: Respiratory
Tissue: Human Secondary Airways (Healthy)
Target: VIP & PACAP
Control Compound: Vasoactive Intestinal Polypeptide (VIP)
Study Type: Organ bath
Functional Endpoint: Bronchodilatation

View assay →

 

Bronchoconstriction in healthy human tertiary or lower airways (lopoxin, oxoeiconsanoid and resolvin E1)

Reference number: B099

Assay type: Respiratory
Tissue: Human Secondary Airways (Healthy)
Target: VIP & PACAP
Control Compound: Vasoactive Intestinal Polypeptide (VIP)
Study Type: Organ bath
Functional Endpoint: Bronchodilatation

View assay →

 

IBD culture study Crohn’s or ulcerative colitis (UC)

Reference number: B106

Tissue: Human GI Mucosal Explants (IBD)
Target: p38 MAP Kinase
Control Compound: BIRB796
Study Type: Ex vivo Cultures
Functional Endpoint: Inflammation

View assay →

 

Contraction in human bladder (muscarinic – carbachol)

Reference number: B107

Assay Type: GU
Tissue: Human Bladder (Healthy)
Target: Muscarinic receptors
Control Compound: Carbachol
Study Type: Organ bath
Functional Endpoint: Contraction

View assay →

 

Contraction, relaxation in human bladder electrically stimulated

Reference number: B108

Assay Type: GU
Tissue: Human Bladder (Healthy)
Target: Muscarinic/ beta-adrenergic receptors/ ion channels
Control Compound: Carbachol/ isoproterenol/ retigabine
Study Type: Organ bath
Functional Endpoint: Modulation of EFS-induced contractions

View assay →

 

Permeability in IBD human gastrointestinal mucosa

Reference number: B109

Assay Type: GI Tract
Tissue: Human Diseased (IBD) Gastrointestinal Mucosa
Target: N/A
Control Compound: Multiple
Study Type: Ussing chamber
Functional Endpoint: Permeability

View assay →

 

Pulmonary arteries

Reference number: B110

Assay Type: GU / Blood Vessels
Tissue: Human Pulmonary Artery (Healthy) / Human Pulmonary Artery (Healthy – Denuded)
Target: Muscarinic Receptors/ Angiotensin receptor/ Nitric oxide donor/ Endothelin receptor/ Prostacyclin receptor/ Prostaglandin EP2 receptor/ Prostaglandin EP4 receptor/ Beta adrenergic receptor
Control Compound: Acetylcholine/ Angiotensin II/ Sildenafil/ U46619/ Endothelin-1/ Iloprost/ Bosentan/ Wire Myography
Study Type: Organ bath
Functional Endpoint: Contractile force/ Contraction/ Relaxation/ Vasoconstriction/ Vasodilatation

View assay →

 

Skin inflammation LPS (acne) (systemic/topical)

Reference number: B111

Assay Type: Human GI Mucosal Explants (IBD)
Tissue: Human Skin Biopsies (Healthy)
Target: TLR4/TLR2 Pathway/ Glucocorticoid receptors/ NLRP3 Inflammasome
Control Compound: Betnovate/ Nitric Oxide 
Study Type: Ex vivo cultures
Functional Endpoint: Cytokine release

View assay →

 

Lung PCLS culture

Reference number: B112

Assay Type: Respiratory
Tissue: Human Precision Cut Lung Slice (PCLS)
Target: TLR4/TLR2 Pathway/ Glucocorticoid receptors/ NLRP3 Inflammasome
Control Compound: Fluticasone/ Roflumilast
Study Type: Ex vivo cultures
Functional Endpoint: Cytokine release

View assay →

 

Skin culture induced psoriasis model (systemic/topical)

Reference number: B113

Assay Type: Skin
Tissue: Human Skin Biopsies (Healthy)
Target:

Glucocorticoid receptors/ Retinoid receptors/ Th17 Pathway

Control Compound: Retigabine/ Betnovate/ Calcipotriol/ ROR gamma antagonist GSK2981278/ Dovonex (topical calcipotriol)/ Dovobet (topical calcipotriol plus Betamethasone)/ Zorac/ Dermovate/ Phase1/Phase 2 metabolic enzymes
Study Type: Ex vivo cultures
Functional Endpoint: Cytokine release/ Gene Expression

View assay →

 

Relaxation in human LES

Reference number: B114

Assay Type: Gastrointestinal (GI) Tract
Tissue: Human Lower esophageal sphincter
Target: TGR5 receptor
Control Compound: Carbachol/ Isoprenaline
Study Type: Organ bath
Functional Endpoint: Contractile force/ Relaxation

View assay →

 

Contraction in human LES

Reference number: B115

Assay Type: Gastrointestinal (GI) Tract
Tissue: Human Lower esophageal sphincter
Target: TGR5 receptor
Control Compound: Carbachol/ Isoprenaline
Study Type: Organ bath
Functional Endpoint: Contractile force/Contraction

View assay →

 

GI metabolism

Reference number: B116

Assay Type: Gastrointestinal (GI) Tract
Tissue: Human Colon/ Human Gastrointestinal Mucosa (Healthy)
Target: Phase1/Phase 2 metabolic enzymes
Control Compound: Phase1/Phase 2 metabolic enzymes
Study Type: Ussing chamber
Functional Endpoint: Metabolism

View assay →

 

Healthy skin culture

Reference number: B117

Assay Type: Skin
Tissue: Human Skin Biopsies (Healthy)
Target: Study Dependant
Control Compound: LPS
Study Type: Ex vivo cultures
Functional Endpoint: Inflammation

View assay →

 

Skin biopsies atopic dermatitis (systemic/topical)

Reference number: B118

Assay Type: Skin
Tissue: Skin Disease Biopsies
Target: Study Dependant
Control Compound: Betamethasone
Study Type: Ex vivo cultures
Functional Endpoint: Inflammation

View assay →

 

Skin biopsies atopic psoraisis (systemic/topical)

Reference number: B119

Assay Type: Skin
Tissue: Skin Disease Biopsies
Target: Study Dependant
Control Compound: Betamethasone
Study Type: Ex vivo cultures
Functional Endpoint: Inflammation

View assay →

 

Skin inflammation PHA (systemic/topical)

Reference number: B120

Assay Type: Skin
Tissue: Human Skin Biopsies (Healthy)
Target: Study Dependant
Control Compound: Betamethasone
Study Type: Ex vivo cultures
Functional Endpoint: Inflammation

View assay →

 

Skin culture induced atopic dermatitis model (systemic/topical)

Reference number: B121

Assay Type: Skin
Tissue: Human Skin Biopsies (Healthy)
Target: TH2 Pathway
Control Compound: Betamethasone
Study Type: Ex vivo cultures
Functional Endpoint: Inflammation

View assay →