Drug Discovery Assays Catalog
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Drug Discovery Assay Catalog
Available Assays:
Vasoconstriction in human coronary arteries (5-HT receptor – 5-HT)
Reference number: B003
| Assay type: | Blood Vessels |
| Tissue: | Human Coronary Artery (Healthy) |
| Target: | 5-HT receptor |
| Control Compound: | 5-HT |
| Study Type: | Wire Myography |
| Functional Endpoint: | Vasoconstriction |
Vasoconstriction in human coronary arteries (Opioid and opioid-like receptors)
Reference number: B004
| Assay type: | Blood Vessels |
| Tissue: | Human Coronary Artery (Healthy) |
| Target: | Opioid & opioid-like receptors |
| Control Compound: | Mephedrone |
| Study Type: | Wire Myography |
| Functional Endpoint: | Vasoconstriction |
Vasoconstriction in human coronary arteries (Angiotensin receptor)
Reference number: B007
| Assay type: | Blood Vessels |
| Tissue: | Human Coronary Artery (Healthy) |
| Target: | Angiotensin receptor |
| Control Compound: | Angiotensin II |
| Study Type: | Organ bath |
| Functional Endpoint: | Vasoconstriction |
Vasoconstriction in human coronary arteries (Vasopressin & oxytocin receptors)
Reference number: B008
| Assay type: | Blood Vessels |
| Tissue: | Human Coronary Artery (Healthy) |
| Target: | Vasopressin & oxytocin receptors |
| Control Compound: | 8-arginine vasopressin |
| Study Type: | Organ bath |
| Functional Endpoint: | Vasoconstriction |
Vasodilatation in human chorionic plate arteries (PDE5)
Reference number: B009
| Assay type: | Blood Vessels |
| Tissue: | Human Chorionic Plate Arteries (Pre-Eclamptic) |
| Target: | PDE5 |
| Control Compound: | Sildenafil |
| Study Type: | Wire Myography |
| Functional Endpoint: | Vasodilatation |
Vasodilatation in human chorionic plate arteries (Bradykinin receptor)
Reference number: B010
| Assay type: | Blood Vessels |
| Tissue: | Human Chorionic Plate Arteries (Healthy) |
| Target: | Bradykinin receptor |
| Control Compound: | Bradykinin |
| Study Type: | Wire Myography |
| Functional Endpoint: | Vasodilatation |
Vasodilatation in human pre-eclamptic chorionic plate arteries (PDE5)
Reference number: B011
| Assay type: | Blood Vessels |
| Tissue: | Human Chorionic Plate Arteries (Pre-Eclamptic) |
| Target: | PDE5 |
| Control Compound: | Sildenafil |
| Study Type: | Wire Myography |
| Functional Endpoint: | Vasodilatation |
Vasodilatation in human pre-eclamptic chorionic plate arteries (Bradykinin receptor)
Reference number: B012
| Assay type: | Blood Vessels |
| Tissue: | Human Chorionic Plate Arteries (Pre-Eclamptic) |
| Target: | Bradykinin receptor |
| Control Compound: | Bradykinin |
| Study Type: | Wire Myography |
| Functional Endpoint: | Vasodilatation |
Vasodilatation in human subcutaneous resistance arteries (Acetylcholine receptor)
Reference number: B016
| Assay type: | Blood Vessels |
| Tissue: | Human Subcutaneous Resistance Artery (Healthy) |
| Target: | Acetylcholine receptor |
| Control Compound: | Acetylcholine |
| Study Type: | Wire Myography |
| Functional Endpoint: | Vasodilatation |
Vasodilatation in human subcutaneous resistance arteries (Vasopressin & oxytocin receptors)
Reference number: B017
| Assay type: | Blood Vessels |
| Tissue: | Human Subcutaneous Resistance Artery (Healthy) |
| Target: | Vasopressin & oxytocin receptors |
| Control Compound: | Desmopressin |
| Study Type: | Wire Myography |
| Functional Endpoint: | Vasodilatation |
Vasodilatation in human subcutaneous resistance arteries (Nitric oxide donor)
Reference number: B019
| Assay type: | Blood Vessels |
| Tissue: | Human Subcutaneous Resistance Artery (Healthy) |
| Target: | Nitric oxide donor |
| Control Compound: | SNP |
| Study Type: | Wire Myography |
| Functional Endpoint: | Vasodilatation |
Vasoconstriction in human subcutaneous resistance arteries (Adrenoceptor)
Reference number: B020
| Assay type: | Blood Vessels |
| Tissue: | Human Subcutaneous Resistance Artery (Healthy) |
| Target: | Adrenoceptor |
| Control Compound: | Phenylephrine |
| Study Type: | Wire Myography |
| Functional Endpoint: | Vasodilatation |
Vasoconstriction in human subcutaneous resistance arteries (Prostanoid receptor)
Reference number: B021
| Assay type: | Blood Vessels |
| Tissue: | Human Subcutaneous Resistance Artery (Healthy) |
| Target: | Prostanoid receptor |
| Control Compound: | U46619 |
| Study Type: | Wire Myography |
| Functional Endpoint: | Vasoconstriction |
Vasodilatation in ischaemic human subcutaneous resistance arteries (Bradykinin receptor)
Reference number: B022
| Assay type: | Blood Vessels |
| Tissue: | Human Subcutaneous Resistance Artery (Ischaemic) |
| Target: | Bradykinin receptor |
| Control Compound: | Bradykinin |
| Study Type: | Wire Myography |
| Functional Endpoint: | Vasodilatation |
Vasoconstriction in human saphenous vein (5-HT receptor)
Reference number: B023
| Assay type: | Blood Vessels |
| Tissue: | Human Saphenous Vein (Healthy) |
| Target: | 5-HT receptor |
| Control Compound: | Sumatriptan |
| Study Type: | Wire Myography |
| Functional Endpoint: | Vasoconstriction |
Vasoconstriction in human coronary arteries (5-HT receptor – Sumatriptan)
Reference number: B028
| Assay type: | Blood Vessels |
| Tissue: | Human Coronary Artery (Healthy) |
| Target: | 5-HT receptor |
| Control Compound: | Sumatriptan |
| Study Type: | Wire Myography |
| Functional Endpoint: | Vasoconstriction |
Vasoconstriction in denuded human coronary arteries (5-HT receptor)
Reference number: B030
| Assay type: | Blood Vessels |
| Tissue: | Human Coronary Artery (Healthy – Denuded) |
| Target: | 5-HT receptor |
| Control Compound: | 5-HT |
| Study Type: | Organ bath |
| Functional Endpoint: | Vasoconstriction |
Vasodilatation in human subcutaneous resistance arteries (PDE3 receptor)
Reference number: B034
| Assay type: | Blood Vessels |
| Tissue: | Human Subcutaneous Resistance Artery (Healthy) |
| Target: | PDE3 |
| Control Compound: | Milrinone |
| Study Type: | Wire Myography |
| Functional Endpoint: | Vasodilatation |
Vasodilatation in human subcutaneous resistance arteries (Bradykinin receptor)
Reference number: B035
| Assay type: | Blood Vessels |
| Tissue: | Human Subcutaneous Resistance Artery (Healthy) |
| Target: | Bradykinin receptor |
| Control Compound: | Bradykinin |
| Study Type: | Wire Myography |
| Functional Endpoint: | Vasodilatation |
Vascular permeability in human subcutaneous resistance arteries (PAR-1, PAR-3 and PAR-4 receptors)
Reference number: B036
| Assay type: | Blood Vessels |
| Tissue: | Human Subcutaneous Resistance Artery (Healthy) |
| Target: | PAR-1, PAR-3 and PAR-4 receptors |
| Control Compound: | Thrombin |
| Study Type: | Perfusion myography |
| Functional Endpoint: | Vascular permeability |
Vasoconstriction in atherosclerotic human subcutaneous resistance arteries (Angiotensin receptor)
Reference number: B037
| Assay type: | Blood Vessels |
| Tissue: | Human Resistance Artery (Atherosclerotic) |
| Target: | Angiotensin receptor |
| Control Compound: | PDA-angiotensin 1 |
| Study Type: | Wire Myography |
| Functional Endpoint: | Vasoconstriction |
Vasodilatation in ischaemic human subcutaneous resistance arteries (Nitric oxide donor)
Reference number: B038
| Assay type: | Blood Vessels |
| Tissue: | Human Subcutaneous Resistance Artery (Ischaemic) |
| Target: | Nitric oxide donor |
| Control Compound: | SNP |
| Study Type: | Wire Myography |
| Functional Endpoint: | Vasodilatation |
Vasodilatation in human skeletal muscle arteries (Acetycholine receptor)
Reference number: B039
| Assay type: | Blood Vessels |
| Tissue: | Human Skeletal Muscle Artery (Healthy) |
| Target: | Acetylcholine receptor |
| Control Compound: | Acetylcholine |
| Study Type: | Wire Myography |
| Functional Endpoint: | Vasodilatation |
Vasodilatation in human skeletal muscle arteries (Nitric oxide donor)
Reference number: B040
| Assay type: | Blood Vessels |
| Tissue: | Human Skeletal Muscle Artery (Healthy) |
| Target: | Nitric oxide donor |
| Control Compound: | SNP |
| Study Type: | Wire Myography |
| Functional Endpoint: | Vasodilatation |
Contractile force in electrically stimulated human atrial pectinate muscle (Adrenoceptors – Isoprenaline)
Reference number: B043
| Assay type: | Cardiac Muscle |
| Tissue: | Human Atrial Pectinate Muscle (Healthy) |
| Target: | Adrenoceptor |
| Control Compound: | Isoprenaline |
| Study Type: | EFS organ bath |
| Functional Endpoint: | Contractile force |
Contractile force in electrically stimulated human ventricular trabeculae muscle (5-HT receptor)
Reference number: B047
| Assay type: | Cardiac Muscle |
| Tissue: | Human Ventricular Trabeculae Muscle (Healthy) |
| Target: | 5-HT receptor |
| Control Compound: | 5-HT |
| Study Type: | EFS organ bath |
| Functional Endpoint: | Contractile force |
Contractile force in electrically stimulated human atrial pectinate muscle (5-HT receptor)
Reference number: B048
| Assay type: | Cardiac Muscle |
| Tissue: | Human Atrial Pectinate Muscle (Healthy) |
| Target: | 5-HT receptor |
| Control Compound: | 5-HT |
| Study Type: | EFS organ bath |
| Functional Endpoint: | Contractile force |
Contractile force in electrically stimulated human atrial pectinate muscle (Adrenoceptors – Salbutamol)
Reference number: B049
| Assay type: | Cardiac Muscle |
| Tissue: | Human Atrial Pectinate Muscle (Healthy) |
| Target: | Adrenoceptor |
| Control Compound: | Salbutamol |
| Study Type: | EFS organ bath |
| Functional Endpoint: | Contractile force |
Contractile force in electrically stimulated human atrial pectinate muscle (PDE3 receptor)
Reference number: B050
| Assay type: | Cardiac Muscle |
| Tissue: | Human Atrial Pectinate Muscle (Healthy) |
| Target: | PDE3 |
| Control Compound: | Milrinone |
| Study Type: | EFS organ bath |
| Functional Endpoint: | Contractile force |
Bronchodilatation in secondary healthy human airways (Adrenoceptor – Isoprenaline)
Reference number: B052
| Assay type: | Respiratory |
| Tissue: | Human Tertiary Or Lower Airways (Healthy) |
| Target: | Adrenoceptor |
| Control Compound: | Isoprenaline |
| Study Type: | Wire Myography |
| Functional Endpoint: | Bronchodilatation |
Bronchoconstriction in secondary asthmatic human airways (Acetylcholine receptor)
Reference number: B053
| Assay type: | Respiratory |
| Tissue: | Human Secondary Airways (Asthmatic) |
| Target: | Acetylcholine receptor |
| Control Compound: | Carbachol |
| Study Type: | Organ bath |
| Functional Endpoint: | Bronchoconstriction |
Bronchodilatation in secondary asthmatic human airways (Adrenoceptor)
Reference number: B054
| Assay type: | Respiratory |
| Tissue: | Human Secondary Airways (Asthmatic) |
| Target: | Adrenoceptor |
| Control Compound: | Salbutamol |
| Study Type: | Organ bath |
| Functional Endpoint: | Bronchodilatation |
Bronchoconstriction in tertiary or lower healthy human airways (Prostanoid receptor)
Reference number: B055
| Assay type: | Respiratory |
| Tissue: | Human Tertiary Or Lower Airways (Healthy) |
| Target: | Prostanoid receptor |
| Control Compound: | U46619 |
| Study Type: | Wire Myography |
| Functional Endpoint: | Bronchoconstriction |
Bronchodilatation in tertiary or lower healthy human airways (Adrenoceptor – Salbutamol)
Reference number: B056
| Assay type: | Respiratory |
| Tissue: | Human Tertiary Or Lower Airways (Healthy) |
| Target: | Adrenoceptor |
| Control Compound: | Salbutamol |
| Study Type: | Wire Myography |
| Functional Endpoint: | Bronchodilatation |
Bronchoconstriction in tertiary or lower healthy human airways (Acetylcholine receptor)
Reference number: B057
| Assay type: | Respiratory |
| Tissue: | Human Tertiary Or Lower Airways (Healthy) |
| Target: | Acetylcholine receptor |
| Control Compound: | Acetylcholine |
| Study Type: | Wire Myography |
| Functional Endpoint: | Bronchoconstriction |
Bronchodilatation in tertiary or lower healthy human airways (Adrenoceptor – Isoprenaline)
Reference number: B058
| Assay type: | Respiratory |
| Tissue: | Human Tertiary Or Lower Airways (Healthy) |
| Target: | Adrenoceptor |
| Control Compound: | Isoprenaline |
| Study Type: | Wire Myography |
| Functional Endpoint: | Bronchodilatation |
Bronchodilatation in secondary COPD human airways (Adrenoceptor)
Reference number: B059
| Assay type: | Respiratory |
| Tissue: | Human Tertiary Or Lower Airways (COPD) |
| Target: | Adrenoceptor |
| Control Compound: | Isoprenaline |
| Study Type: | Wire Myography |
| Functional Endpoint: | Bronchodilatation |
Bronchoconstriction in denuded secondary healthy human airways (Acetylcholine receptor)
Reference number: B060
| Assay type: | Respiratory |
| Tissue: | Human Secondary Airways (Healthy – Denuded) |
| Target: | Acetylcholine receptor |
| Control Compound: | Carbachol |
| Study Type: | Organ bath |
| Functional Endpoint: | Bronchoconstriction |
Bronchoconstriction in denuded secondary healthy human airways (Histamine receptor)
Reference number: B061
| Assay type: | Respiratory |
| Tissue: | Human Secondary Airways (Healthy – Denuded) |
| Target: | Histamine receptor |
| Control Compound: | Histamine |
| Study Type: | Organ bath |
| Functional Endpoint: | Bronchoconstriction |
Ion channel function in healthy human tracheal mucosa (Adrenoceptors)
Reference number: B062
| Assay type: | Respiratory |
| Tissue: | Human Trachea (Mucosa) (Healthy) |
| Target: | Adrenoceptor |
| Control Compound: | Isoprenaline |
| Study Type: | Ussing chamber |
| Functional Endpoint: | Ion channel function |
Ion channel function in healthy human tracheal mucosa (Sodium channels)
Reference number: B063
| Assay type: | Respiratory |
| Tissue: | Human Trachea (Mucosa) (Healthy) |
| Target: | Sodium channels |
| Control Compound: | Amiloride |
| Study Type: | Ussing chamber |
| Functional Endpoint: | Ion channel function |
Bronchodilatation in tertiary or lower human airways (Adrenoceptors – Formoterol)
Reference number: B065
| Assay type: | Respiratory |
| Tissue: | Human Tertiary Or Lower Airways (Healthy) |
| Target: | Adrenoceptor |
| Control Compound: | Formoterol |
| Study Type: | Wire Myography |
| Functional Endpoint: | Bronchodilatation |
Bronchodilatation in tertiary or lower human airways (Adrenoceptors – Salbutamol)
Reference number: B066
| Assay type: | Respiratory |
| Tissue: | Human Tertiary Or Lower Airways (Healthy) |
| Target: | |
| Control Compound: | Salbutamol |
| Study Type: | Wire Myography |
| Functional Endpoint: | Bronchodilatation |
Bronchodilatation in tertiary or lower asthmatic human airways (Adrenoceptor – Formoterol)
Reference number: B067
| Assay type: | Respiratory |
| Tissue: | Human Tertiary Or Lower Airways (Asthmatic) |
| Target: | Adrenoceptor |
| Control Compound: | Formoterol |
| Study Type: | Wire Myography |
| Functional Endpoint: | Bronchodilatation |
Bronchodilatation in tertiary or lower asthmatic human airways (Adrenoceptor – Salbutamol)
Reference number: B068
| Assay type: | Respiratory |
| Tissue: | Human Tertiary Or Lower Airways (Asthmatic) |
| Target: | Adrenoceptor |
| Control Compound: | Salbutamol |
| Study Type: | Wire Myography |
| Functional Endpoint: | Bronchodilatation |
Bronchodilatation in tertiary or lower asthmatic human airways (Adrenoceptor – Salmeterol)
Reference number: B069
| Assay type: | Respiratory |
| Tissue: | Human Tertiary Or Lower Airways (Asthmatic) |
| Target: | Adrenoceptor |
| Control Compound: | Salmeterol |
| Study Type: | Wire Myography |
| Functional Endpoint: | Bronchodilatation |
Relaxation in human bladder (Adrenoceptor – Isoproterenol)
Reference number: B070
| Assay type: | GU |
| Tissue: | Human Bladder (Healthy) |
| Target: | Adrenoceptor |
| Control Compound: | Isoproterenol |
| Study Type: | Organ bath |
| Functional Endpoint: | Relaxation |
Relaxation in human ureter (Adrenoceptor – Isoprenaline)
Reference number: B071
| Assay type: | GU |
| Tissue: | Human Ureter (Healthy) |
| Target: | Adrenoceptor |
| Control Compound: | Isoprenaline |
| Study Type: | Organ bath |
| Functional Endpoint: | Relaxation |
Contraction in human urethra (Adrenoceptor – Phenylephrine)
Reference number: B072
| Assay type: | GU |
| Tissue: | Human Urethra (Healthy) |
| Target: | Adrenoceptor |
| Control Compound: | Phenylephrine |
| Study Type: | Organ bath |
| Functional Endpoint: | Contraction |
Contraction in human uterus (Vasopressin & Oxytocin Receptor – Oxytocin)
Reference number: B078
| Assay type: | GU |
| Tissue: | Human Uterus (Healthy) |
| Target: | Vasopressin & oxytocin receptors |
| Control Compound: | Oxytocin |
| Study Type: | Organ bath |
| Functional Endpoint: | Contraction |
Contraction in human uterus (Vasopressin & Oxytocin Receptor – Vasopressin)
Reference number: B079
| Assay type: | GU |
| Tissue: | Human Uterus (Healthy) |
| Target: | Vasopressin & oxytocin receptors |
| Control Compound: | Vasopressin |
| Study Type: | Organ bath |
| Functional Endpoint: | Contraction |
Relaxation in human uterus (Nitric Oxide Donor)
Reference number: B081
| Assay type: | GU |
| Tissue: | Human Uterus (Healthy) |
| Target: | Nitric oxide donor |
| Control Compound: | SNP |
| Study Type: | Organ bath |
| Functional Endpoint: | Relaxation |
Relaxation in human uterus (Adrenoceptor – Isoprenaline)
Reference number: B082
| Assay type: | GU |
| Tissue: | Human Uterus (Healthy) |
| Target: | Adrenoceptor |
| Control Compound: | Isoprenaline |
| Study Type: | Organ bath |
| Functional Endpoint: | Relaxation |
Relaxation in human uterus (Calcium Channels)
Reference number: B083
| Assay type: | GU |
| Tissue: | Human Uterus (Healthy) |
| Target: | Calcium channels |
| Control Compound: | Isradipine |
| Study Type: | Organ bath |
| Functional Endpoint: | Relaxation |
Contractile force in electrically stimulated human colon (Acetylcholine Esterase)
Reference number: B086
| Assay type: | GI Tract |
| Tissue: | Human Stomach (Healthy) |
| Target: | Acetylcholine esterase |
| Control Compound: | Galantamine |
| Study Type: | EFS organ bath |
| Functional Endpoint: | Contractile force |
Contractile force in electrically stimulated human colon (Opioid & Opioid like receptors)
Reference number: B087
| Assay type: | GI Tract |
| Tissue: | Human Colon |
| Target: | Opioid & opioid-like receptors |
| Control Compound: | Meptazinol |
| Study Type: | EFS organ bath |
| Functional Endpoint: | Contractile force |
Contractile force in electrically stimulated human stomach (Motilin receptor)
Reference number: B092
| Assay type: | GI Tract |
| Tissue: | Human Stomach (Healthy) |
| Target: | Motilin receptor |
| Control Compound: | Erythromycin |
| Study Type: | EFS organ bath |
| Functional Endpoint: | Contractile force |
Permeability in healthy human gastrointestinal mucosa
Reference number: B093
| Assay type: | GI Tract |
| Tissue: | Human Gastrointestinal Mucosa |
| Target: | N/A |
| Control Compound: | Multiple |
| Study Type: | Ussing chamber |
| Functional Endpoint: | Permeability |
Ion channel function in isolated healthy human gastrointestinal mucosa (Chloride channels)
Reference number: B094
| Assay type: | GI Tract |
| Tissue: | Human Gastrointestinal Mucosa (Healthy) |
| Target: | Chloride channels |
| Control Compound: | Cholera toxin |
| Study Type: | Ussing chamber |
| Functional Endpoint: | Ion channel function |
Contractile force in electrically stimulated human ventricular trabeculae muscle (adrenoceptor)
Reference number: B095
| Assay type: | Cardiac Muscle |
| Tissue: | Human Ventricular Trabeculae Muscle (Healthy) |
| Target: | Adrenoceptor |
| Control Compound: | Isoprenaline |
| Study Type: | EFS organ bath |
| Functional Endpoint: | Contractile force |
Contractile force in eletrically stimulated human ventricular trabeculae muscle (acetylcholine receptor)
Reference number: B096
| Assay type: | Cardiac Muscle |
| Tissue: | Human Ventricular Trabeculae Muscle (Healthy) |
| Target: | Acetylcholine receptor |
| Control Compound: | Acetylcholine |
| Study Type: | EFS organ bath |
| Functional Endpoint: | Contractile force |
Vasoconstriction in human subcutaneous resistance arteries (5-HT receptor)
Reference number: B097
| Assay type: | Blood Vessels |
| Tissue: | Human Subcutaneous Resistance Artery (Healthy) |
| Target: | 5-HT receptor |
| Control Compound: | 5-HT |
| Study Type: | Wire Myography |
| Functional Endpoint: | Vasoconstriction |
Bronchodilatation in healthy human secondary airways (VIP & PACAP receptors)
Reference number: B098
| Assay type: | Respiratory |
| Tissue: | Human Secondary Airways (Healthy) |
| Target: | VIP & PACAP |
| Control Compound: | Vasoactive Intestinal Polypeptide (VIP) |
| Study Type: | Organ bath |
| Functional Endpoint: | Bronchodilatation |
Bronchoconstriction in healthy human tertiary or lower airways (lopoxin, oxoeiconsanoid and resolvin E1)
Reference number: B099
| Assay type: | Respiratory |
| Tissue: | Human Secondary Airways (Healthy) |
| Target: | VIP & PACAP |
| Control Compound: | Vasoactive Intestinal Polypeptide (VIP) |
| Study Type: | Organ bath |
| Functional Endpoint: | Bronchodilatation |
IBD culture study Crohn’s or ulcerative colitis (UC)
Reference number: B106
| Tissue: | Human GI Mucosal Explants (IBD) |
| Target: | p38 MAP Kinase |
| Control Compound: | BIRB796 |
| Study Type: | Ex vivo Cultures |
| Functional Endpoint: | Inflammation |
Contraction in human bladder (muscarinic – carbachol)
Reference number: B107
| Assay Type: | GU |
| Tissue: | Human Bladder (Healthy) |
| Target: | Muscarinic receptors |
| Control Compound: | Carbachol |
| Study Type: | Organ bath |
| Functional Endpoint: | Contraction |
Contraction, relaxation in human bladder electrically stimulated
Reference number: B108
| Assay Type: | GU |
| Tissue: | Human Bladder (Healthy) |
| Target: | Muscarinic/ beta-adrenergic receptors/ ion channels |
| Control Compound: | Carbachol/ isoproterenol/ retigabine |
| Study Type: | Organ bath |
| Functional Endpoint: | Modulation of EFS-induced contractions |
Permeability in IBD human gastrointestinal mucosa
Reference number: B109
| Assay Type: | GI Tract |
| Tissue: | Human Diseased (IBD) Gastrointestinal Mucosa |
| Target: | N/A |
| Control Compound: | Multiple |
| Study Type: | Ussing chamber |
| Functional Endpoint: | Permeability |
Pulmonary arteries
Reference number: B110
| Assay Type: | GU / Blood Vessels |
| Tissue: | Human Pulmonary Artery (Healthy) / Human Pulmonary Artery (Healthy – Denuded) |
| Target: | Muscarinic Receptors/ Angiotensin receptor/ Nitric oxide donor/ Endothelin receptor/ Prostacyclin receptor/ Prostaglandin EP2 receptor/ Prostaglandin EP4 receptor/ Beta adrenergic receptor |
| Control Compound: | Acetylcholine/ Angiotensin II/ Sildenafil/ U46619/ Endothelin-1/ Iloprost/ Bosentan/ Wire Myography |
| Study Type: | Organ bath |
| Functional Endpoint: | Contractile force/ Contraction/ Relaxation/ Vasoconstriction/ Vasodilatation |
Skin inflammation LPS (acne) (systemic/topical)
Reference number: B111
| Assay Type: | Human GI Mucosal Explants (IBD) |
| Tissue: | Human Skin Biopsies (Healthy) |
| Target: | TLR4/TLR2 Pathway/ Glucocorticoid receptors/ NLRP3 Inflammasome |
| Control Compound: | Betnovate/ Nitric Oxide |
| Study Type: | Ex vivo cultures |
| Functional Endpoint: | Cytokine release |
Lung PCLS culture
Reference number: B112
| Assay Type: | Respiratory |
| Tissue: | Human Precision Cut Lung Slice (PCLS) |
| Target: | TLR4/TLR2 Pathway/ Glucocorticoid receptors/ NLRP3 Inflammasome |
| Control Compound: | Fluticasone/ Roflumilast |
| Study Type: | Ex vivo cultures |
| Functional Endpoint: | Cytokine release |
Skin culture induced psoriasis model (systemic/topical)
Reference number: B113
| Assay Type: | Skin |
| Tissue: | Human Skin Biopsies (Healthy) |
| Target: |
Glucocorticoid receptors/ Retinoid receptors/ Th17 Pathway |
| Control Compound: | Retigabine/ Betnovate/ Calcipotriol/ ROR gamma antagonist GSK2981278/ Dovonex (topical calcipotriol)/ Dovobet (topical calcipotriol plus Betamethasone)/ Zorac/ Dermovate/ Phase1/Phase 2 metabolic enzymes |
| Study Type: | Ex vivo cultures |
| Functional Endpoint: | Cytokine release/ Gene Expression |
Relaxation in human LES
Reference number: B114
| Assay Type: | Gastrointestinal (GI) Tract |
| Tissue: | Human Lower esophageal sphincter |
| Target: | TGR5 receptor |
| Control Compound: | Carbachol/ Isoprenaline |
| Study Type: | Organ bath |
| Functional Endpoint: | Contractile force/ Relaxation |
Contraction in human LES
Reference number: B115
| Assay Type: | Gastrointestinal (GI) Tract |
| Tissue: | Human Lower esophageal sphincter |
| Target: | TGR5 receptor |
| Control Compound: | Carbachol/ Isoprenaline |
| Study Type: | Organ bath |
| Functional Endpoint: | Contractile force/Contraction |
GI metabolism
Reference number: B116
| Assay Type: | Gastrointestinal (GI) Tract |
| Tissue: | Human Colon/ Human Gastrointestinal Mucosa (Healthy) |
| Target: | Phase1/Phase 2 metabolic enzymes |
| Control Compound: | Phase1/Phase 2 metabolic enzymes |
| Study Type: | Ussing chamber |
| Functional Endpoint: | Metabolism |
Healthy skin culture
Reference number: B117
| Assay Type: | Skin |
| Tissue: | Human Skin Biopsies (Healthy) |
| Target: | Study Dependant |
| Control Compound: | LPS |
| Study Type: | Ex vivo cultures |
| Functional Endpoint: | Inflammation |
Skin biopsies atopic dermatitis (systemic/topical)
Reference number: B118
| Assay Type: | Skin |
| Tissue: | Skin Disease Biopsies |
| Target: | Study Dependant |
| Control Compound: | Betamethasone |
| Study Type: | Ex vivo cultures |
| Functional Endpoint: | Inflammation |
Skin biopsies atopic psoraisis (systemic/topical)
Reference number: B119
| Assay Type: | Skin |
| Tissue: | Skin Disease Biopsies |
| Target: | Study Dependant |
| Control Compound: | Betamethasone |
| Study Type: | Ex vivo cultures |
| Functional Endpoint: | Inflammation |
Skin inflammation PHA (systemic/topical)
Reference number: B120
| Assay Type: | Skin |
| Tissue: | Human Skin Biopsies (Healthy) |
| Target: | Study Dependant |
| Control Compound: | Betamethasone |
| Study Type: | Ex vivo cultures |
| Functional Endpoint: | Inflammation |
Skin culture induced atopic dermatitis model (systemic/topical)
Reference number: B121
| Assay Type: | Skin |
| Tissue: | Human Skin Biopsies (Healthy) |
| Target: | TH2 Pathway |
| Control Compound: | Betamethasone |
| Study Type: | Ex vivo cultures |
| Functional Endpoint: | Inflammation |
REPROCELL Brand
Predictive Drug Discovery Assay Services
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