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REPROCELL StemRNA Neuro AD-mutation

Code: RCDN002
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StemRNA Neuro AD-Mutation Neurons (RCDN002N)

Human Brain AlzheimerÕs Disease Model Neurons derived by Transfection.

  • Frozen as a suspension of individualized human progenitor cells
  • Prepared using the same manufacturing process as wild-type ReproNeuro
  • Constructed by transfection with a mutated (P117L) Presenilin 1(PS1) gene introduced into an iPS cell line
  • Rapidly differentiates into neurons during in vitro growth and maturation (~2 weeks)
  • Expresses multiple neuron-specific markers; indicating a mixed population of neuron types
  • Shows an increased ratio of amyloid β (Aβ42 / Aβ40) peptides as observed in AlzheimerÕs disease brain pathology
  • ReproNeuro RCDN001N (Lot A) is an isogenic control (the identical iPS cell line prior to transfection)
  • Developed with iCeMS (Institute for Integrated Cell-Material Sciences, Kyoto, Japan)

ReproNeuro iPSC-derived neurons are delivered as a suspension of frozen single cells that retain structural and functional integrity, and high viability thanks to REPROCELLÕs proprietary cryopreservation technology. Thawed and plated, ReproNeuro cells mature during 2-3 weeks of culture on surfaces treated with ReproNeuro Coat (RCDN201).

Schematic showing preparation of neural progenitor cells from human iPS cells which were transfected mutated (P117L) presenilin 1gene

Product Name

StemRNA Neuro AD-Mutation Neurons

Catalog Number

RCDN002N

Size

3 × 10cells

Storage and Stability

Store in liquid nitrogen

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