Stemolecule™ (Small molecules) NEW

Product Classification : Small molecule / CytokinesResearch Theme : ES/iPS cells

Stemgent

  • Stemgent’s portfolio is quite extentsive for stem cells
  • The products have high purity and low lot-to-lot variability
  • Used globally
Catalog No. Product Overview Quantity Price
04-0079

★NEW!

WH-4-023
A potent Src and LCK inhibitor (IC50< 10 nM) 2 mg Ask
04-0080

★NEW!

SB590885
A potent for and selective (>10-fold selectivity against C-RAF) inhibitor of B-RAF kinase 2 mg Ask
04-0081

★NEW!

IM-12
A potent and intracellular inhibitor of GSK-3β activates downstream components of canonical Wnt signaling and increasing β-catenin levels 2 mg Ask
04-0004 CHIR99021 The most selective inhibitor of glycogen synthase kinase 3β (GSK-3β) reported to date 2 mg Ask
04-0004-10 10 mg Ask
04-0004-02 CHIR99021
(10mM sol.)
2 mg Ask
04-0074 LDN-193189 A cell permeable small molecule inhibitor of bone morphogenetic protein (BMP) type I receptors ALK2 and ALK3 (IC50 = 5 nM and 30 nM respectively) 2 mg Ask
04-0074-10 10 mg Ask
04-0074-02 LDN-193189
(10mM sol.)
2 mg Ask
04-0006 PD0325901 A small molecule targeting mitogen-activated protein kinase (MAPK/ERK kinase or MEK) with potential antineoplastic activity 2 mg Ask
04-0006-10 10 mg Ask
04-0006-02 PD0325901
(10mM sol.)
2 mg Ask
04-0034 Wnt Inhibitor IWP-2 An antagonist of the Wnt/β-catenin pathway 2 mg Ask
04-0035 Wnt Inhibitor IWP-3 An antagonist of the Wnt/β-catenin pathway 2 mg Ask
04-0036 Wnt Inhibitor IWP-4 An antagonist of the Wnt/β-catenin pathway 2 mg Ask
04-0046 XAV939 An antagonist of the Wnt/β-catenin pathway 2 mg Ask
04-0052 A769662 A cell-permeable small molecule that activates AMP-activated protein kinase(AMPK) 10 mg Ask
04-0014 A83-01 A selective inhibitor of the transforming growth factor-beta (TGF-β) type I receptor ALK5, the Activin/Nodal receptor ALK4, and the nodal receptor ALK7 2 mg Ask
04-0014-10 10 mg Ask
04-0015 ALK5 Inhibitor A selective and ATP-competitive inhibitor of the TGF-β family type I receptor activin receptor-like kinase (ALK5) 1 mg Ask
04-0021 All-Trans Retinoic Acid An oxidized form of Vitamin A and functions as a signaling molecule for various developmental pathways that control differentiation and proliferation 100 mg Ask
SRP002 ec23® (ATRA Alt.) a stable synthetic retinoid based on all-trans retinoic acid (ATRA) 5 mg Ask
SRP002-2 5 mg×2 Ask
04-0077 AM580 A highly specific small molecule agonist for retinoic acid receptor alpha (RARα) 5 mg Ask
04-0051 BI-D1870 A highly specific small molecule inhibitor of Ribosomal S6 Kinase (RSK1, RSK2, RSK3 and RSK4 isoforms), which acts as an ATP-competitive inhibitor of the N-terminal AGC kinase domain of RSK 10 mg Ask
04-0003 BIO(6-bromoindirubin-3′-oxime) A potent, reversible and ATP-competitive inhibitor for GSK-3α/β in the Wnt signaling pathway 2 mg Ask
04-0002 BIX01294 A histone lysine methyltransferase (HMTase) inhibitor that selectively inhibits the G9a HMTase and the generation of histone H3 lysine 9 methylation (H3K9me2) 5 mg Ask
04-0078 CD437 A retinoic acid receptor gamma (RARγ)-selective retinoid agonist shown to effectively inhibit growth and induce apoptosis of a variety of cancer cells 5 mg Ask
04-0022 Cyclopamine A steroid alkaloid isolated from the corn lily (Veratrum californicum) and originally identified as a teratogenic agent 2 mg Ask
04-0041 DAPT A cell-permeable dipeptide, inhibits γ-secretase and indirectly inhibits Notch, a γ-secretase substrate 5 mg Ask
04-0024 Dorsomorphin A potent inhibitor of AMP-activated protein kinase (AMPK) (Ki=109nM) and bone morphogenic protein (BMP) signaling 2 mg Ask
04-0016 Doxycycline hyclate (Dox) A broad spectrum antibiotic derivative of tetracycline and an inhibitor of matrix metalloproteinases 10 mg Ask
04-0025 Forskolin A natural compound produced by the Indian Coleus plant (Coleus forskohlii) 10 mg Ask
04-0047 GDC-0941 A cell-permeable, selective small molecule that inhibits Class I phosphatidylinositide 3-kinase (PI3K) 5 mg Ask
04-0049 GSK429286A A cell-permeable, selective small molecule inhibitor of Rho-associated, coiled-coil containing protein kinase (ROCK) 2 mg Ask
04-0026 IDE-1 A high throughput screen as an inducer of definitive endoderm (IDE) from embryonic stem (ES) cells 2 mg Ask
04-0027 IDE-2 A high throughput screen as an inducer of definitive endoderm (IDE) from embryonic stem (ES) cells 2 mg Ask
04-0037 IPA-3 An allosteric inhibitor of p21-activated kinase (Pak) activation 5 mg Ask
04-0028 KAAD-Cyclopamine A sonic hedgehog antagonist known to target Smoothened 100 μg Ask
04-0054 LY411575 A selective, cell permeable, small molecule gamma secretase inhibitor which blocks Notch activation 5 mg Ask
04-0008 PD173074 A potent, cell-permeable ATP-competitive inhibitor of fibroblast growth factor (FGF) receptor 2 mg Ask
04-0039 Pifithrin-μ A small molecule which inhibits p53 binding to mitochondria by reducing its affinity for antiapoptotic proteins Bcl-2 and Bcl-XL 5 mg Ask
04-0009 Purmorphamine A small molecule that promotes the differentiation of human and murine mesenchymal progenitor cells into osteoblasts 5 mg Ask
04-0072 Pyrintegrin A selective, cell permeable small molecule that was identified to enhance the survival of human embryonic stem cells (hESCs) 1 mg Ask
04-0013 R(+)Bay K 8644 An L-type Ca2+ channel activator1,2. This molecule has recently been demonstrated to enhance reprogramming efficiency 5 mg Ask
04-0001 RG108

A cell-permeablesmall molecule that inhibits DNA methyltransferases

10 mg Ask
04-0030 ROCK II Inhibitor

A specific inhibitor for type 2 Rho-associated, coiled-coil containing protein kinase (ROCK)

2 mg Ask
04-0010 SB431542

An inhibitor of the transforming growth factor-beta 1 (TGF-β1) activin receptor-like kinases (ALKs)

5 mg Ask
04-0010-10 10 mg Ask
04-0010-05 SB431542
(10 mM sol.)
5 mg Ask
04-0011 SC1 (Pluripotin)

A small molecule that regulate mouse embryonic stem (ES) cell self-renewal

1 mg Ask
04-0032 SHH Antagonist

A Sonic hedgehog (SHH) signaling antagonist that functions by alcohol dehydrogenase 7 (Adh7) inhibition

2 mg Ask
04-0031 SMO Antagonist

An analog of SANT-2

2 mg Ask
04-0005 Sodium Butyrate

A known inhibitor of histone deacetylases (HDACs)

500 mg Ask
04-0017 Thiazovivin

A selective, cell permeable small molecule that directly targets Rho-associated kinase (ROCK)

1 mg Ask
04-0007 Valproic Acid

A histone deacetylase (HDAC) inhibitor which improves reprogramming efficiency by at least 100 fold

5 g Ask

Publications

  • Zimmer B, Piao J, Ramnarine K, Tomishima MJ, Tabar V, Studer L. Derivation of Diverse Hormone-Releasing Pituitary Cells from Human Pluripotent Stem Cells. Stem Cell Reports. 2016 Jun 14;6(6):858-72. doi: 10.1016/j.stemcr.2016.05.005. PubMed PMID: 27304916.
  • Rigamonti A, Repetti GG, Sun C, Price FD, Reny DC, Rapino F, Weisinger K, Benkler C, Peterson QP, Davidow LS, Hansson EM, Rubin LL. Large-Scale Production of Mature Neurons from Human Pluripotent Stem Cells in a Three-Dimensional Suspension Culture System. Stem Cell Reports. 2016 Jun 14;6(6):993-1008. doi:10.1016/j.stemcr.2016.05.010. PubMed PMID: 27304920.
  • Nishimura K, Doi D, Samata B, Murayama S, Tahara T, Onoe H, Takahashi J. Estradiol Facilitates Functional Integration of iPSC-Derived Dopaminergic Neurons into Striatal Neuronal Circuits via Activation of Integrin α5β1. Stem Cell Reports. 2016 Mar 16. pii: S2213-6711(16)00059-X. doi:10.1016/j.stemcr.2016.02.008. [Epub ahead of print] PubMed PMID: 26997644.
  • Shahbazi E, Moradi S, Nemati S, Satarian L, Basiri M, Gourabi H, Zare Mehrjardi N, Günther P, Lampert A, Händler K, Hatay FF, Schmidt D, Molcanyi M, Hescheler J, Schultze JL, Saric T, Baharvand H. Conversion of Human Fibroblasts to Stably Self-Renewing Neural Stem Cells with a Single Zinc-Finger Transcription Factor. Stem Cell Reports. 2016 Mar 22. pii: S2213-6711(16)00064-3. doi: 10.1016/j.stemcr.2016.02.013. [Epub ahead of print] PubMed PMID: 27052315.
  • Nefzger CM, Jardé T, Rossello FJ, Horvay K, Knaupp AS, Powell DR, Chen J, Abud HE, Polo JM. A Versatile Strategy for Isolating a Highly Enriched Population of Intestinal Stem Cells. Stem Cell Reports. 2016 Feb 18. pii: S2213-6711(16)00031-X. doi: 10.1016/j.stemcr.2016.01.014. [Epub ahead of print] PubMed PMID: 26923822.
  • Bhutani K, Nazor KL, Williams R, Tran H, Dai H, D?akula , Cho EH, Pang AW, Rao M, Cao H, Schork NJ, Loring JF. Whole-genome mutational burden analysis of three pluripotency induction methods. Nat Commun. 2016 Feb 19;7:10536. doi:10.1038/ncomms10536. PubMed PMID: 26892726.
  • Fernandes HJ, Hartfield EM, Christian HC, Emmanoulidou E, Zheng Y, Booth H, Bogetofte H, Lang C, Ryan BJ, Sardi SP, Badger J, Vowles J, Evetts S, Tofaris GK, Vekrellis K, Talbot K, Hu MT, James W, Cowley SA, Wade-Martins R. ER Stress and Autophagic Perturbations Lead to Elevated Extracellular α-Synuclein in GBA-N370S Parkinson’s iPSC-Derived Dopamine Neurons. Stem Cell Reports. 2016 Feb 17. pii:S2213-6711(16)00030-8. doi: 10.1016/j.stemcr.2016.01.013. [Epub ahead of print] PubMed PMID: 26905200.
  • Imaizumi K, et al. (2015) Controlling the Regional Identity of hPSC-Derived Neurons to Uncover Neuronal Subtype Specificity of Neurological Disease Phenotypes. Stem Cell Reports.
  • Attari F, et al. (2014) Efficient induction of pluripotency in primordial germ cells by dual inhibition of TGF-β and ERK signaling pathways. Stem Cells Dev. 23(10):1050-61.
  • Li, W, et al. (2014) Generation of human-induced pluripotent stem cells in the absence of exogenous Sox2. Stem Cells. 27:2992-3000.
  • Itokazu T, et al. (2014) Involvement of Wnt/β-catenin signaling in the development of neuropathic pain. Neurosci Res. 79:34-40.
  • Blaschke K, et al. (2013) Vitamin C induces Tet-dependent DNA demethylation and a blastocyst-like state in ES cells. Nature. 500(7461):222-6.
  • Sundberg M, et al. (2013) Improved cell therapy protocols for Parkinson’s disease based on differentiation efficiency and safety of hESC-, hiPSC-, and non-human primate iPSC-derived dopaminergic neurons. Stem Cells. 31(8):1548-62.
  • Koehler KR, et al. (2013) Generation of inner ear sensory epithelia from pluripotent stem cells in 3D culture. Nature. 500(7461):217-21.
  • Uyama M, et al. (2013) Wasf2: A novel target of intermittent parathyroid hormone administration. Int J Mol Med. 31(5):1243-7.
  • Chesebro JE, et al. (2013) Interplay between a Wnt-dependent organiser and the Notch segmentation clock regulates posterior development in Periplaneta americana. Biol Open. 2(2):227-37.
  • Kinney MA, et al. (2013) Temporal modulation of β-catenin signaling by multicellular aggregation kinetics impacts embryonic stem cell cardiomyogenesis. Stem Cells Dev. 22(19):2665-77.
  • Rezania A. et al. (2013) Enrichment of human embryonic stem cell-derived NKX6.1-expressing pancreatic progenitor cells accelerates the maturation of insulin-secreting cells in vivo. Stem Cells. 31(11):2432-42.
  • Chien Y, et al. (2012) Corneal repair by human corneal keratocyte-reprogrammed iPSCs and amphiphatic carboxymethyl-hexanoyl chitosan hydrogel. Biomaterials. 33(32):8003-16.
  • Farin HF, et al. (2012) Redundant Sources of Wnt Regulate Intestinal Stem Cells and Promote Formation of Paneth Cells. Gastroenterology. 143(6):1518-1529.e7.
  • Hudson J, et al. (2012) Primitive cardiac cells from human embryonic stem cells. Stem Cells Dev. 21(9):1513-23.
  • Nagy K, et al. (2011) Induced pluripotent stem cell lines derived from equine fibroblasts. Stem Cell Rev. 7(3):693-702.
  • Wang B, et al. (2011) Reprogramming efficiency and quality of induced Pluripotent Stem Cells (iPSCs) generated from muscle-derived fibroblasts of mdx mice at different ages. PLoS Curr. 3:RRN1274.
  • Haara O, et al. (2011) Ectodysplasin and Wnt pathways are required for salivary gland branching morphogenesis. Development. 138(13):2681-91.
  • Lin T, et al. (2009) A chemical platform for improved induction of human iPSCs. Nat Methods. 6(11):805-8.