ReproNeuro AD-mutation NEW

Product Classification : hiPSC-NeuronsResearch Theme : Alzheimer's disease, Drug Effect Test, Pharmacological Effectiveness Test, Tailor-made Disease Model

Neural progenitor cells from human iPS cells transfected mutated presenilin1 (PS1) gene

  • Mutated (P117L) presenilin 1(PS1) gene is transfected in human iPS cells
  • Differentiation into neural progenitor cells
  • Shows an increased ratio of amyloid beta (Abeta42/Abeta40)
  • Use as Alzheimer’s disease model cells
  • Parental ReproNeuro cell line is an isogenic control
  • Delivery in frozen cells
  • Get neurons only 14 days after thawing
  • Developed with iCeMS

※Storage:LN2

Overview

Induction into neural progenitor cells from human iPS cells which are transfected mutated (P117L) presenilin 1 gene

Reference

Sakurai K, et al. “Efficient integration of transgenes into a defined locus in human embryonic stem cells.”Nucleic Acids Res. (2010): Apr;38(7):e96.

Product List

Catalog No. Product Price
RCDN002N ReproNeuro AD-mutation : 3 x 106 cells Ask

Related Products

Neural progenitor cells from Alzheimer’s disease patient-derived iPS cells

ReproNeuro AD-patient 1 (Cat. No. : RCDN003P)

  

Disease model cells for your request

We can provide the disease model cells for your request. This service include acquisition of a sample from a patient for a source of iPS cells,establishment of human iPS cell by RNA technology and differentiation into functional cells (Cardiomyocytes, Hepatocytes and Neurons). You can request any one or more of the processes described.

Product List

Catalog No. Product Price
RCDN101

ReproNeuro Culture Medium™

Culture medium :For the neurons of ReproNeuro series

  • ReproNeuro Culture Medium™(40 mL)
  • Additive(520 μL)
Ask
RCDN102

ReproNeuro MQ medium™

Culture medium :For the MEA assay

  • ReproNeuro MQ medium™(40 mL)
  • Additive(520 μL)
Ask
RCDN201

ReproNeuro Coat™(150 μL)

Coating solution :For the coating

Ask

Literature

  • Makoto Honda, Itsunari Minami, Norie Tooi, Nobuhiro Morone, Hisae Nishioka, Kengo Uemura, Ayae Kinoshita, John E. Heuser, Norio Nakatsuji, Kazuhiro Aiba. The modeling of Alzheimer's disease by the overexpression of mutant Presenilin 1 in human embryonic stem cells. Biochemical and Biophysical Research Communications 469, 3(2016):587-592

  • Sakurai K, et al. “Efficient integration of transgenes into a defined locus in human embryonic stem cells.”Nucleic Acids Res. (2010): Apr;38(7):e96.