Atelocollagen sponge, MIGHTY

Product Classification : Atelocollagen for Cell Culture│KOKENResearch Theme : 3D culture, Cancer

Atelocollagen sponge, MIGHTY

Collagen sponge derived from bovine dermal type I collagen shows resistance to compressive loading (maximum is 30 kPa, single load). Culturing with dynamic stimulus enables analysis of cell function in a condition close to in vivo.

Applications

  • Cell culture under dynamic stimuli
  • 3D cell culture
  • Carrier for cell transplant

Features

  • Retains structural rigidity during repeated compression loading of 10-20 kPa.
  • Sized for 96-wellplates.

Overview

Applications

  • Cell culture under dynamic stimuli
  • 3D cell culture
  • Carrier for cell transplant

Features

  • Retains structural rigidity during repeated compression loading of 10-20 kPa.
  • Sized for 96-wellplates.

Data

“Mechanical stimulus culture assay using MIGHTY.”
(K. Shimomura, K. Nakata et al. Osaka University, Faculty of Medicine)

Fourty kPa of repeated compressive load for 1 hour induced the expression of PEG2, IL6 and IL8, which are correlated to arthritis, after three days cultivation on MIGHTY.
Dexamethasone (Dex), anti-inflammatory agent, reduced the expression of PEG2, IL6 and IL8 in a concentration-dependent manner. These results indicate MIGHTY can be used for in vitro arthritis models.

Data

Publications

  1. Shiozaki Y, et al. Enhanced in vivo osteogenesis by nanocarrier-fused bone morphogenetic protein-4. (2013) Int J Nanomedicine. 8:1349-1360.
  2. Akamine Y, et al. Prolonged matrix metalloproteinase-3 high expression after cycliccompressive load on human synovial cells in three-dimensional cultured tissue. (2012) Int J Oral Maxillofac Surg. 41(7):874-881.
  3. Muroi Y, et al. Effects of compressive loading on human synovium-derived cells. (2007) J Dent Res. 86(8):786-791.

Product List

Catalog No. Product Quantity Storage Data sheet Price
KKN-CSM-25 Atelocollagen sponge, MIGHTY 25 pcs (sterile) 25 mg/btl Room Temperature
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KKN-CSM-50 Atelocollagen sponge, MIGHTY 50 pcs (sterile) 50 pcs/btl Room Temperature
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