iMatrix-411 features make it an ideal matrix for some cell culture applications:
iMatrix-411 is a highly purified and refined product of human recombinant laminin-411 (E8 fragment) expressed by CHO-S cells. Laminin-411 is found predominantly expressed in the vascular endothelial basement membrane1 and in Langerhans islet capillary endothelial cells of the pancreas.2
As a cell culture ECM-substrate iMatrix-411 can assist in establishing human endothelial cell primary cultures from fresh human bio-specimens.
Human iPS cells, when cultured on iMatrix-411, are robustly induced (>95%) to differentiate into endothelial progenitor cells with angiogenesis capacity.1 Other published reports have used iMatrix-411 and iMatrix-511 in a step-wise protocol to generate cholangiocytes capable of forming 3D cyst-structures from iPSC-derived hepatoblastic cells.3
iMatrix-411 Endothelial Cell Substrate
Purified Laminin-411 E8 proteolytic fragment
Storage and Stability
Store at 4 °C and protect from light exposure. Stable for 2 years from manufacturing date.
Activity: Kd for integrin binding
Notice To Purchaser
REPROCELL is a licensed distributor of Matrixome cell culture substrates to the global market
iMatrix-411 is suitable for use as a substrate for culture of various cell types, but most notably for vascular endothelial cells.
CHO-S cell expression
Matrixome Corporation (Japan)