iMatrix-221's features make it an ideal matrix for some cell culture applications:
iMatrix-221 is a highly purified and refined product of human recombinant laminin-221 (E8 fragment) expressed by CHO-S cells. Laminin-221 is found predominantly in the basal lamina of striated muscle tissues. Expression deficiencies are implicated in muscular dystophy and cardiomyopathies.1
Laminins of the α-2 type are also a predomiant form found in the human adult heart tissue.2 Cultivation of iPSC-drived cardiomyocytes on iMatrix-221 has been demonstrated to maintain strong contractility in attached monolayer culture.3
iMatrix-221 Cardiac and Myoblast Cell Culture Substrate
Purified Laminin-221 E8 proteolytic fragment
Storage and Stability
Store at 4 °C and protect from light exposure. Stable for 2 years from manufacturing date.
Activity: Kd for integrin binding
Notice To Purchaser
REPROCELL is a licensed distributor of Matrixome cell culture substrates to the global market.
iMatrix-221 is suitable for use as a substrate for culture of various myoblast cell types, but most notably for cardiomyocytes.
CHO-S cell expression
Matrixome Corporation (Japan)