Publications: Biopta

Following is a list of publications in scientific journals in which REPROCELL Center for Predictive Drug Discovery (formerly Biopta)’s assay services have been made use in. Many of these papers have been authored or co-authored by Biopta staff.


A novel role for CCR3 in promoting airways hyperreactivity; Role for CCR3-muscarinic M3 receptor heterodimers. 

Bacon, K et al.
European Respiratory Journal Sep 2015, 46 (suppl 59) 
DOI: 10.1183/13993003.congress-2015.OA288.


Molecular Profiling of Multiplexed Gene Markers to Assess Viability of Ex Vivo Human Colon Explant Cultures.

Drew et al.
Bioresearch Open Access 2015; 4:425-430


Effects of Recombinant Human Type I Pancreatic Elastase on Human Atherosclerotic Arteries. 

Burke, S.K. et al.
J Cardiovasc Pharmacol 2014; 64:530–535


The contribution of VEGF signalling to fostamatinib-induced blood pressure elevation. 

Skinner M., Philp K., Lengel D., Coverley L., Lamm Bergström E., Glaves P., Musgrove H., Prior H., Braddock M., Huby, R., Curwen J.O., Duffy P., Harmer A.R.
British Journal of Pharmacology (2014) 171 2308–2320.


Tumor stromal architecture can define the intrinsic tumor response to VEGF-targeted therapy.

Smith N.R. et al.
Clinical Cancer Research 19 (24) 6943-56 (2013)


Comparison of the Intrinsic Vasorelaxant and Inotropic Effects of the Antiarrhythmic Agents Vernakalant and Flecainide in Human Isolated Vascular and Cardiac Tissues

Lynch J.J., Regan C.P., Gregory N., Beatch G.N., Gleim, G.W. and Morabito, C.J.
J Cardiovasc Pharmacol  2013; 61:226–232.


The inability of tegaserod to affect platelet aggregation and coronary artery tone at supratherapeutic concentrations.  

Higgins L. et al. (Biopta conduced human coronary artery experiments)
Naunyn-Schmiedeberg's Arch Pharmacol  (2012) 385:103–109


Discovery of N-(3(1-Methyl-1,2,3,6-tetrahydropyridin-4-yl)-1H-indol-6-yl) thiopene-2-carboximidamideas a Selective Inhibitor of Human Neuronal Nitric Oxide Synthase (nNOS) for the Treatment of Pain. 

Annedi S.C., Maddaford S.P., Mladenova G., Ramnauth J., Rakhit S., Andrews J.S., Lee D.K.H., Zhang D., Porreca F., Bunton D.C., Christie L.
Journal of Medicinal Chemistry 20: 7408:7416 (2011).


The Use of Functional Human Tissues in Drug Development. 

Bunton D.C.
Cell and Tissue Banking 12: 31-32 (2011).


An antibody targeted to VEGFR-2 Ig domains 4-7 inhibits VEGFR-2 activation and VEGFR-2-dependent angiogenesis without affecting ligand binding.

Kendrew J. et al.
Molecular Cancer Therapeutics 10: 770-783 (2011)


The Use of Functional Human Tissues in Drug Development. 

Bunton D.C.
ATLA 38: 27-30 (2010).


A Novel System for the Investigation of Microvascular Dysfunction including Vascular Permeability and Flow Mediated Dilation in Pressurised Human Arteries. 

Moss E., Lynagh S., Smith D., Kelly S., McDaid A., Bunton D.C.
Pharmacological and Toxicological Methods 62: 40-46 (2010).


Could Fresh Human Tissue play a Key Role in Drug Development? 

Bunton D.C.
ATLA 1: 5-10 (2009).


Evaluation of Equine Laminar Vein Function: Harvesting, Dissection and the use of Functional Methods to Distinguish between Veins and Arteries. 

Keen J.A., Hillier C., McGorum B.C., Bunton D.C., Nally J.E.
Pharmacological and Toxicological Methods 57: 92-99 (2008).


Functional Human Tissue.

Bunton D.C.
Drug Discovery Today (12): 382:388 (2007).


The Clinical Relevance of Adrenomedullin: A Promising Profile? 

Bunton D.C., Petrie M.C., Hillier C., Johnston F., McMurray J.J.V.
Pharmacology and Therapeutics 103: 179-201 (2004).


Relaxation to Bradykinin in Bovine Pulmonary Supernumerary Arteries can be mediated by both a Nitric Oxide-Dependent and –Independent Mechanism.

Tracey A., Bunton D.C., Irvine J., MacDonald A., Shaw A.M.
British Journal of Pharmacology 137: 538-544 (2002).


Regulation of Sensitivity to 5-hydroxytryptamine in Pulmonary Supernumerary but not Conventional Arteries by a 5HT1D- like Receptor. 

Shaw A.S., Bunton D.C., Brown T., Irvine J., MacDonald A.
European Journal of Pharmacology 408: 69-82 (2000).


5-hydroxytryptamine- and U46619-Mediated Vasoconstriction in Bovine Pulmonary Conventional and Super-Numerary Arteries: Effect of Endogenous Nitric Oxide.

Bunton D., MacDonald A., Brown T., Tracey A., McGrath J.C.
Clinical Science 98: 81-89 (2000).