Atelocollagen sponge, MIGHTY

Catalog KKN-CSM-50
Size 25 pieces
50 pieces
Price
$900.00
$900.00
Availability In stock
Catalog
KKN-CSM-25, KKN-CSM-50

Product Overview

A "physically strong" collagen sponge (96-well plate size) derived from bovine dermal type I collagen that shows resistance to compressive loading. Culturing with dynamic stimulus (such as pressure) can mimic in-vivo-like cell response as shown in some arthritic cell culture models.

Applications

  • Cell culture under dynamic stimuli
  • 3D cell culture
  • Carrier for cell transplant

Features

  • Retains structural rigidity during repeated compression loading of 10-20 kPa
  • Sized for 96-wellplates

Data

“Mechanical stimulus culture assay using MIGHTY.”
(K. Shimomura, K. Nakata et al. Osaka University, Faculty of Medicine)

Forty kPa of repeated compressive load for 1 hour induced the expression of PEG2, IL6 and IL8, which are correlated to arthritis, after three days cultivation on MIGHTY.
Dexamethasone (Dex), anti-inflammatory agent, reduced the expression of PEG2, IL6 and IL8 in a concentration-dependent manner. These results indicate MIGHTY can be used for in vitro arthritis models.

Data


Product Specifications

Product Name
Atelocollagen sponge, MIGHTY
Catalog Number
KKN-CSM-25, KKN-CSM-50
Size
25 pieces
50 pieces
Storage and Stability
Store at Room Temperature
Sterility
sterile
Notice To Purchaser
REPROCELL is a licensed global distributor of KOKEN’s collagen-derived products everywhere, except for Japan.
Manufacturer
Koken Co., Ltd. (Japan)


References

  1. Shiozaki Y, et al. Enhanced in vivo osteogenesis by nanocarrier-fused bone morphogenetic protein-4. (2013) Int J Nanomedicine. 8:1349-1360.
  2. Akamine Y, et al. Prolonged matrix metalloproteinase-3 high expression after cycliccompressive load on human synovial cells in three-dimensional cultured tissue. (2012) Int J Oral Maxillofac Surg. 41(7):874-881.
  3. Muroi Y, et al. Effects of compressive loading on human synovium-derived cells. (2007) J Dent Res. 86(8):786-791.

Product Specifications

Product Name
Atelocollagen sponge, MIGHTY
Catalog Number
KKN-CSM-25, KKN-CSM-50
Size
25 pieces
50 pieces
Storage and Stability
Store at Room Temperature
Sterility
sterile
Notice To Purchaser
REPROCELL is a licensed global distributor of KOKEN’s collagen-derived products everywhere, except for Japan.
Manufacturer
Koken Co., Ltd. (Japan)

References

  1. Shiozaki Y, et al. Enhanced in vivo osteogenesis by nanocarrier-fused bone morphogenetic protein-4. (2013) Int J Nanomedicine. 8:1349-1360.
  2. Akamine Y, et al. Prolonged matrix metalloproteinase-3 high expression after cycliccompressive load on human synovial cells in three-dimensional cultured tissue. (2012) Int J Oral Maxillofac Surg. 41(7):874-881.
  3. Muroi Y, et al. Effects of compressive loading on human synovium-derived cells. (2007) J Dent Res. 86(8):786-791.