Function and identity of iPS cell-derived cardiomyocyte clusters

The cells included in ReproCardio kit has been extensively characterized for their identity and function.

Expression of heart cell markers

The expression of various cardiomyocyte-specific marker genes and cardiac ion channels have been confirmed.

[Movie] A beating cardiomyocyte cluster on MEA

ReproCardio cardiomyocyte clusters show robust beating. Extracellular electrophysiological recordings can be made by placing the clusters on electrodes like those of MEA system.

[Movie] in vitro ECG-like waveform resembling in vivo heart activity

ReproCardio cardiomyocyte clusters, when extracellular recording is performed, can generate ECG-like waveform. The effects of various compounds can be functionally evaluated using this in vivo-like system.

Accurate replication of the in vivo response of the heart to cardiotoxic compounds

ReproCardio cardiomyocytes have been extensively characterized for their functional responsiveness to the known cardiotoxic compounds. In all our tests, including assays of cardiotoxic compounds not correctly identified by the hERG assay, ReproCardio has generated results in complete agreement with clinical findings. For the detailed information about ReproCardio’s compound response, please refer to our web page for QTempo, an assay service for cardiotoxicity testing using ReproCardio cardiomyocytes.